6GXW
Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 4
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
A | 0004407 | molecular_function | histone deacetylase activity |
A | 0005634 | cellular_component | nucleus |
A | 0006338 | biological_process | chromatin remodeling |
A | 0046872 | molecular_function | metal ion binding |
B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
B | 0004407 | molecular_function | histone deacetylase activity |
B | 0005634 | cellular_component | nucleus |
B | 0006338 | biological_process | chromatin remodeling |
B | 0046872 | molecular_function | metal ion binding |
C | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
C | 0004407 | molecular_function | histone deacetylase activity |
C | 0005634 | cellular_component | nucleus |
C | 0006338 | biological_process | chromatin remodeling |
C | 0046872 | molecular_function | metal ion binding |
D | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
D | 0004407 | molecular_function | histone deacetylase activity |
D | 0005634 | cellular_component | nucleus |
D | 0006338 | biological_process | chromatin remodeling |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 501 |
Chain | Residue |
A | ASP186 |
A | HIS188 |
A | ASP285 |
A | FGN504 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue K A 502 |
Chain | Residue |
A | ASP184 |
A | ASP186 |
A | HIS188 |
A | SER207 |
A | VAL208 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue K A 503 |
Chain | Residue |
A | PHE197 |
A | SER200 |
A | VAL203 |
A | SER243 |
A | HOH634 |
site_id | AC4 |
Number of Residues | 10 |
Details | binding site for residue FGN A 504 |
Chain | Residue |
A | LYS20 |
A | HIS141 |
A | HIS142 |
A | ASP186 |
A | HIS188 |
A | PHE216 |
A | ASP285 |
A | HIS292 |
A | TYR341 |
A | ZN501 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue DMF A 505 |
Chain | Residue |
A | LYS330 |
A | VAL331 |
A | VAL361 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue DMF A 506 |
Chain | Residue |
A | CYS15 |
A | PHE21 |
A | ARG24 |
A | TYR110 |
A | GLY137 |
A | TRP140 |
A | HOH640 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue GOL A 507 |
Chain | Residue |
A | GLU194 |
A | THR219 |
A | GLY220 |
A | THR221 |
A | ASN223 |
A | LEU234 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue ZN B 501 |
Chain | Residue |
B | ASP186 |
B | HIS188 |
B | ASP285 |
B | FGN504 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue K B 502 |
Chain | Residue |
B | ASP184 |
B | ASP186 |
B | HIS188 |
B | SER207 |
B | VAL208 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue K B 503 |
Chain | Residue |
B | PHE197 |
B | SER200 |
B | VAL203 |
B | SER243 |
B | HOH657 |
site_id | AD2 |
Number of Residues | 12 |
Details | binding site for residue FGN B 504 |
Chain | Residue |
A | ASP50 |
B | LYS20 |
B | ASP100 |
B | HIS141 |
B | HIS142 |
B | ASP186 |
B | HIS188 |
B | ASP285 |
B | PRO291 |
B | HIS292 |
B | TYR341 |
B | ZN501 |
site_id | AD3 |
Number of Residues | 3 |
Details | binding site for residue DMF C 801 |
Chain | Residue |
A | ARG239 |
C | ASP388 |
C | ASP390 |
site_id | AD4 |
Number of Residues | 4 |
Details | binding site for residue ZN C 802 |
Chain | Residue |
C | ASP186 |
C | HIS188 |
C | ASP285 |
C | FGN805 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue K C 803 |
Chain | Residue |
C | ASP184 |
C | ASP186 |
C | HIS188 |
C | SER207 |
C | VAL208 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue K C 804 |
Chain | Residue |
C | PHE197 |
C | SER200 |
C | VAL203 |
C | SER243 |
C | HOH982 |
site_id | AD7 |
Number of Residues | 11 |
Details | binding site for residue FGN C 805 |
Chain | Residue |
C | LYS20 |
C | ASP100 |
C | HIS141 |
C | HIS142 |
C | ASP186 |
C | HIS188 |
C | ASP285 |
C | PRO291 |
C | HIS292 |
C | TYR341 |
C | ZN802 |
site_id | AD8 |
Number of Residues | 8 |
Details | binding site for residue GOL C 806 |
Chain | Residue |
C | PHE233 |
C | LEU234 |
C | ASN246 |
C | HIS189 |
C | GLU194 |
C | GLY220 |
C | THR221 |
C | ASN223 |
site_id | AD9 |
Number of Residues | 4 |
Details | binding site for residue ZN D 501 |
Chain | Residue |
D | ASP186 |
D | HIS188 |
D | ASP285 |
D | FGN504 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue K D 502 |
Chain | Residue |
D | ASP184 |
D | ASP186 |
D | HIS188 |
D | SER207 |
D | VAL208 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue K D 503 |
Chain | Residue |
D | PHE197 |
D | SER200 |
D | VAL203 |
D | SER243 |
D | HOH622 |
site_id | AE3 |
Number of Residues | 11 |
Details | binding site for residue FGN D 504 |
Chain | Residue |
C | ASP50 |
D | LYS20 |
D | ASP100 |
D | HIS141 |
D | HIS142 |
D | ASP186 |
D | HIS188 |
D | ASP285 |
D | HIS292 |
D | TYR341 |
D | ZN501 |
site_id | AE4 |
Number of Residues | 9 |
Details | binding site for residue GOL D 505 |
Chain | Residue |
D | HIS189 |
D | GLU194 |
D | THR219 |
D | GLY220 |
D | THR221 |
D | ASN223 |
D | PHE233 |
D | LEU234 |
D | ASN246 |