6GWR
Structure of the kinase domain of human DDR1 in complex with a potent and selective inhibitor of DDR1 and DDR2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Epithelial discoidin domain-containing receptor 1 | polymer | 315 | 35754.1 | 2 | UniProt (Q08345) Pfam (PF07714) In PDB | Homo sapiens (Human) | Epithelial discoidin domain receptor 1,CD167 antigen-like family member A,Cell adhesion kinase,Discoidin receptor tyrosine kinase,HGK2,Mammary carcinoma kinase 10,MCK-10,Protein-tyrosine kinase 3A,Protein-tyrosine kinase RTK-6,TRK E,Tyrosine kinase DDR,Tyrosine-protein kinase CAK |
| 2 | A, B | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{N}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide | non-polymer | 560.6 | 2 | Chemie (FEW) | |||
| 3 | A, B | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 15 | Chemie (EDO) | |||
| 5 | water | water | 18.0 | 639 | Chemie (HOH) |
Sequence modifications
A, B: 601 - 913 (UniProt: Q08345)
| PDB | External Database | Details |
|---|---|---|
| Ser 599 | - | expression tag |
| Met 600 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71508.2 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2628.6 | |
| All* | Total formula weight | 74136.8 |
