Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue FEW A 1001 |
| Chain | Residue |
| A | VAL624 |
| A | THR701 |
| A | ASP702 |
| A | TYR703 |
| A | MET704 |
| A | PHE762 |
| A | HIS764 |
| A | LEU773 |
| A | ALA783 |
| A | ASP784 |
| A | EDO1012 |
| A | ALA653 |
| A | HOH1253 |
| A | LYS655 |
| A | GLU672 |
| A | ILE675 |
| A | MET676 |
| A | LEU679 |
| A | ILE685 |
| A | MET699 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1002 |
| Chain | Residue |
| A | SER788 |
| A | ARG789 |
| A | ASN790 |
| A | LEU791 |
| A | HOH1165 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 1003 |
| Chain | Residue |
| A | HIS745 |
| A | ALA748 |
| A | GLN749 |
| A | SER752 |
| A | HIS902 |
| A | ALA906 |
| A | HOH1164 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1004 |
| Chain | Residue |
| A | ARG755 |
| A | ARG903 |
| A | HOH1124 |
| A | HOH1171 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1005 |
| Chain | Residue |
| A | ARG872 |
| A | PRO874 |
| A | ALA875 |
| B | GLY801 |
| B | ARG802 |
| B | ARG903 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 1006 |
| Chain | Residue |
| A | TRP834 |
| A | PHE845 |
| A | GLY846 |
| A | LEU870 |
| A | SER871 |
| A | EDO1013 |
| A | HOH1184 |
| B | LYS671 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1007 |
| Chain | Residue |
| A | TRP827 |
| A | PHE845 |
| A | TYR869 |
| A | LEU870 |
| A | TRP888 |
| A | HOH1151 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1008 |
| Chain | Residue |
| A | ARG866 |
| A | HOH1143 |
| A | HOH1172 |
| B | LEU670 |
| B | LYS674 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1009 |
| Chain | Residue |
| A | ARG678 |
| A | LEU760 |
| A | ASN761 |
| B | GLY846 |
| B | LEU848 |
| B | EDO1007 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1010 |
| Chain | Residue |
| A | LEU670 |
| A | VAL673 |
| A | LYS674 |
| B | ARG866 |
| B | EDO1005 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1011 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1012 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1013 |
| Chain | Residue |
| A | TRP834 |
| A | MET838 |
| A | EDO1006 |
| A | HOH1184 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1014 |
| Chain | Residue |
| A | ALA875 |
| A | PRO877 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1015 |
| Chain | Residue |
| A | MET787 |
| A | ALA793 |
| A | TYR796 |
| A | ARG798 |
| A | GLU907 |
| site_id | AD7 |
| Number of Residues | 17 |
| Details | binding site for residue FEW B 1001 |
| Chain | Residue |
| B | ALA783 |
| B | ASP784 |
| B | HOH1191 |
| B | VAL624 |
| B | ALA653 |
| B | LYS655 |
| B | GLU672 |
| B | MET676 |
| B | LEU679 |
| B | MET699 |
| B | THR701 |
| B | ASP702 |
| B | TYR703 |
| B | MET704 |
| B | PHE762 |
| B | HIS764 |
| B | LEU773 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 1002 |
| Chain | Residue |
| A | GLY801 |
| A | ARG802 |
| A | ARG903 |
| B | ARG872 |
| B | PRO874 |
| B | ALA875 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 1003 |
| Chain | Residue |
| A | LYS671 |
| B | TRP834 |
| B | PHE845 |
| B | LEU870 |
| B | SER871 |
| B | HOH1197 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1004 |
| Chain | Residue |
| B | TRP827 |
| B | PHE845 |
| B | TYR869 |
| B | LEU870 |
| B | TRP888 |
| B | HOH1152 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1005 |
| Chain | Residue |
| A | MET600 |
| A | LYS674 |
| A | EDO1010 |
| B | GLU855 |
| B | GLU859 |
| B | ARG866 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1006 |
| Chain | Residue |
| B | MET787 |
| B | ALA793 |
| B | TYR796 |
| B | ARG798 |
| B | HOH1112 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 1007 |
| Chain | Residue |
| A | EDO1009 |
| B | GLY794 |
| B | ARG808 |
| B | GLN843 |
| B | ASP850 |
| B | HOH1139 |
| B | HOH1140 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1008 |
| Chain | Residue |
| A | MET838 |
| B | GLN800 |
| B | ALA803 |
Functional Information from PROSITE/UniProt
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV |
| Chain | Residue | Details |
| A | PHE762-VAL774 | |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. NLYagdYYR |
| Chain | Residue | Details |
| A | ASN790-ARG798 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16337946","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"24509848","evidenceCode":"ECO:0000269"}]} |
