6GW3

Structure of TKS from Cannabis sativa in complex with CoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	3,5,7-trioxododecanoyl-CoA synthase	polymer	388	42873.3	3	UniProt (B1Q2B6) Pfam (PF00195) Pfam (PF02797)	Cannabis sativa (Hemp)	Olivetol synthase,Polyketide synthase-1,Tetraketide synthase
2	D (D)	3,5,7-trioxododecanoyl-CoA synthase,3,5,7-trioxododecanoyl-CoA synthase	polymer	489	54640.8	1	UniProt (B1Q2B6) Pfam (PF00195) Pfam (PF02797)	Cannabis sativa (Hemp)	Olivetol synthase,Polyketide synthase-1,Tetraketide synthase,Olivetol synthase,Polyketide synthase-1,Tetraketide synthase
3	E, G, I, J (A, B, C, D)	COENZYME A	non-polymer		767.5	4	Chemie (COA)
4	F, H (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
5	K, L, M, N (A, B, C, D)	water	water		18.0	1256	Chemie (HOH)

Sequence modifications

A, B, C: 2 - 385 (UniProt: B1Q2B6)

PDB	External Database	Details
Gly -2	-	expression tag
Ala -1	-	expression tag
Met 0	-	expression tag
Ala 1	-	expression tag

D: -99 - -2 (UniProt: B1Q2B6)

PDB	External Database	Details
Gly -103	-	expression tag
Ala -102	-	expression tag
Met -101	-	expression tag
Ala -100	-	expression tag

D: 2 - 385 (UniProt: B1Q2B6)

PDB	External Database	Details
Ala -1	-	linker
Met 0	-	linker
Ala 1	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	183260.7
Non-Polymers*	Number of molecules	6
	Total formula weight	3282.4
All*	Total formula weight	186543.1

*Water molecules are not included.