6GW3
Structure of TKS from Cannabis sativa in complex with CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0016829 | molecular_function | lyase activity |
| A | 0030639 | biological_process | polyketide biosynthetic process |
| A | 1901696 | biological_process | cannabinoid biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0016829 | molecular_function | lyase activity |
| B | 0030639 | biological_process | polyketide biosynthetic process |
| B | 1901696 | biological_process | cannabinoid biosynthetic process |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0016114 | biological_process | terpenoid biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0016829 | molecular_function | lyase activity |
| C | 0030639 | biological_process | polyketide biosynthetic process |
| C | 1901696 | biological_process | cannabinoid biosynthetic process |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0016114 | biological_process | terpenoid biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0016829 | molecular_function | lyase activity |
| D | 0030639 | biological_process | polyketide biosynthetic process |
| D | 1901696 | biological_process | cannabinoid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue COA A 401 |
| Chain | Residue |
| A | LYS55 |
| A | ALA302 |
| A | HOH526 |
| A | HOH572 |
| A | HOH629 |
| A | HOH683 |
| A | HOH713 |
| A | SER56 |
| A | CSD157 |
| A | GLU200 |
| A | LEU261 |
| A | LYS263 |
| A | GLY299 |
| A | GLY300 |
| A | LYS301 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 402 |
| Chain | Residue |
| A | SER126 |
| A | ASP185 |
| A | MET187 |
| A | PHE208 |
| A | HOH502 |
| A | HOH518 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue COA B 401 |
| Chain | Residue |
| B | LYS55 |
| B | CSD157 |
| B | GLU200 |
| B | LEU261 |
| B | LYS263 |
| B | GLY299 |
| B | GLY300 |
| B | LYS301 |
| B | ALA302 |
| B | HOH529 |
| B | HOH561 |
| B | HOH562 |
| B | HOH661 |
| B | HOH684 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PEG B 402 |
| Chain | Residue |
| B | CSD157 |
| B | ASP185 |
| B | MET187 |
| B | GLY249 |
| B | HOH503 |
| B | HOH507 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue COA C 400 |
| Chain | Residue |
| C | LYS55 |
| C | SER56 |
| C | CSD157 |
| C | GLU200 |
| C | LEU261 |
| C | LYS263 |
| C | GLY299 |
| C | GLY300 |
| C | LYS301 |
| C | ALA302 |
| C | HOH549 |
| C | HOH582 |
| C | HOH673 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue COA D 400 |
| Chain | Residue |
| D | LYS51 |
| D | LYS55 |
| D | CSD157 |
| D | LEU199 |
| D | GLU200 |
| D | LEU261 |
| D | LYS263 |
| D | GLY299 |
| D | GLY300 |
| D | LYS301 |
| D | ALA302 |
| D | HOH513 |
| D | HOH599 |
| D | HOH617 |
| D | HOH652 |
Functional Information from PROSITE/UniProt
| site_id | PS00441 |
| Number of Residues | 17 |
| Details | CHALCONE_SYNTH Chalcone and stilbene synthases active site. RVmMyQlGCYGGGTvLR |
| Chain | Residue | Details |
| D | ARG149-ARG165 | |
| A | ARG149-ARG165 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10023","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
