6GR9
Human AURKC INCENP complex bound to VX-680
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Aurora kinase C | polymer | 274 | 32167.1 | 1 | UniProt (Q9UQB9) Pfam (PF00069) In PDB | Homo sapiens (Human) | Aurora 3,Aurora/IPL1-related kinase 3,Aurora-related kinase 3,Aurora/IPL1/Eg2 protein 2,Serine/threonine-protein kinase 13,Serine/threonine-protein kinase aurora-C |
2 | B | Inner centromere protein | polymer | 70 | 8302.4 | 1 | UniProt (Q9NQS7) Pfam (PF03941) In PDB | Homo sapiens (Human) | |
3 | A | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE | non-polymer | 464.6 | 1 | Chemie (VX6) | |||
4 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
5 | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A: 36 - 305 (UniProt: Q9UQB9)
B: 835 - 903 (UniProt: Q9NQS7)
PDB | External Database | Details |
---|---|---|
Gly 32 | - | expression tag |
Ala 33 | - | expression tag |
Asn 34 | - | expression tag |
Ser 35 | - | expression tag |
Asp 136 | Glu 102 | conflict |
PDB | External Database | Details |
---|---|---|
Met 834 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 40469.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 560.6 | |
All* | Total formula weight | 41030.2 |