6GR9
Human AURKC INCENP complex bound to VX-680
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aurora kinase C | polymer | 274 | 32167.1 | 1 | UniProt (Q9UQB9) Pfam (PF00069) | Homo sapiens (Human) | Aurora 3,Aurora/IPL1-related kinase 3,Aurora-related kinase 3,Aurora/IPL1/Eg2 protein 2,Serine/threonine-protein kinase 13,Serine/threonine-protein kinase aurora-C |
| 2 | B (B) | Inner centromere protein | polymer | 70 | 8302.4 | 1 | UniProt (Q9NQS7) Pfam (PF03941) | Homo sapiens (Human) | |
| 3 | C (A) | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE | non-polymer | 464.6 | 1 | Chemie (VX6) | |||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A: 36 - 305 (UniProt: Q9UQB9)
B: 835 - 903 (UniProt: Q9NQS7)
| PDB | External Database | Details |
|---|---|---|
| Gly 32 | - | expression tag |
| Ala 33 | - | expression tag |
| Asn 34 | - | expression tag |
| Ser 35 | - | expression tag |
| Asp 136 | Glu 102 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 834 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40469.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 560.6 | |
| All* | Total formula weight | 41030.2 |
