6GR9

Human AURKC INCENP complex bound to VX-680

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue VX6 A 401

Chain	Residue
A	GLY50
A	ALA183
A	HOH526
A	PHE54
A	ALA70
A	GLU121
A	TYR122
A	ALA123
A	PRO124
A	GLY126
A	LEU173

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site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 402

Chain	Residue
A	SER77
A	ARG114
A	HOH504

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGKFGNVYlArlkeshfi..........VALK

Chain	Residue	Details
A	LEU49-LYS72

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKpeNLLL

Chain	Residue	Details
A	VAL162-LEU174

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by AURKB and AURKC => ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:27332895

Chain	Residue	Details
B	THR892

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by AURKB and AURKC => ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:27332895

Chain	Residue	Details
B	SEP893
A	LEU106

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by AURKB and AURKC => ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:27332895, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SEP894

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER899

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