6GPX
CRYSTAL STRUCTURE OF CCR2A IN COMPLEX WITH MK-0812
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2 | polymer | 349 | 39654.6 | 2 | UniProt (P41597) UniProt (P00268) Pfam (PF00001) | Homo sapiens (Human) | CCR2,Monocyte chemoattractant protein 1 receptor,MCP-1-R,Rd,CCR2,Monocyte chemoattractant protein 1 receptor,MCP-1-R |
| 2 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | D, E, F, G, H... (A, B) | OLEIC ACID | non-polymer | 282.5 | 14 | Chemie (OLA) | |||
| 4 | O, S (A, B) | [(3~{S},4~{S})-3-methoxyoxan-4-yl]-[(1~{R},3~{S})-3-propan-2-yl-3-[[3-(trifluoromethyl)-7,8-dihydro-5~{H}-1,6-naphthyridin-6-yl]carbonyl]cyclopentyl]azanium | non-polymer | 470.5 | 2 | Chemie (F7N) | |||
| 5 | T, U (A, B) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A, B: 29 - 231 (UniProt: P41597)
A, B: 232 - null (UniProt: P00268)
A, B: null - 372 (UniProt: P41597)
| PDB | External Database | Details |
|---|---|---|
| Tyr 70 | Cys 70 | conflict |
| Asn 175 | Gly 175 | conflict |
A, B: null - 372 (UniProt: P41597)
| PDB | External Database | Details |
|---|---|---|
| Asp 292 | Ala 241 | conflict |
| Glu 373 | - | expression tag |
| Val 374 | - | expression tag |
| Leu 375 | - | expression tag |
| Phe 376 | - | expression tag |
| Gln 377 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79309.2 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 4961.0 | |
| All* | Total formula weight | 84270.2 |
