6GPX
CRYSTAL STRUCTURE OF CCR2A IN COMPLEX WITH MK-0812
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004950 | molecular_function | chemokine receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006935 | biological_process | chemotaxis |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0043448 | biological_process | alkane catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004950 | molecular_function | chemokine receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0006935 | biological_process | chemotaxis |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0043448 | biological_process | alkane catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN43-TYR70 | |
| B | GLN43-TYR70 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 50 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS71-TYR80 | |
| A | ASP137-THR153 | |
| B | LYS71-TYR80 | |
| B | ASP137-THR153 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU81-HIS100 | |
| B | LEU81-HIS100 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 112 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | SER101-LYS114 | |
| A | THR179-ARG206 | |
| A | GLN320-GLN336 | |
| B | SER101-LYS114 | |
| B | THR179-ARG206 | |
| B | GLN269-GLN285 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU115-ILE136 | |
| B | LEU115-ILE136 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL154-PHE178 | |
| B | VAL154-PHE178 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN207-LEU226 | |
| B | ASN207-LEU226 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL295-PHE319 | |
| B | VAL244-PHE268 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA337-GLY360 | |
| B | ALA286-GLY309 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by JAK2 => ECO:0000269|PubMed:9670957 |
| Chain | Residue | Details |
| A | TYR139 | |
| B | TYR139 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00241, ECO:0000269|PubMed:10216292 |
| Chain | Residue | Details |
| A | CYS237 | |
| A | CYS240 | |
| A | CYS270 | |
| A | CYS273 | |
| B | CYS229 | |
| B | CYS229 | |
| B | CYS230 | |
| B | CYS230 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: N-formylmethionine => ECO:0000269|PubMed:1637309 |
| Chain | Residue | Details |
| A | MET232 | |
| B | MET229 |
