6GJQ
human NBD1 of CFTR in complex with nanobody T27
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Cystic fibrosis transmembrane conductance regulator | polymer | 261 | 29218.4 | 4 | UniProt (Q20BJ8) Pfam (PF00005) UniProt (by SIFTS) (P13569) | Homo sapiens (Human) | ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B, D, F, H (B, D, F, H) | Nanobody T27 | polymer | 147 | 15911.5 | 4 | Lama glama (llama) | ||
| 3 | I, J, K, L (A, C, E, G) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 4 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 449 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 387 - 646 (UniProt: Q20BJ8)
| PDB | External Database | Details |
|---|---|---|
| Ser 386 | - | expression tag |
| Pro 492 | Ser 492 | engineered mutation |
| Pro 534 | Ala 534 | engineered mutation |
| Thr 539 | Ile 539 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 180519.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2028.7 | |
| All* | Total formula weight | 182548.2 |
