6GJQ

human NBD1 of CFTR in complex with nanobody T27

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
E	0005524	molecular_function	ATP binding
E	0016887	molecular_function	ATP hydrolysis activity
G	0005524	molecular_function	ATP binding
G	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue ATP A 701

Chain	Residue
A	SER459
A	HOH801
E	SER495
A	THR460
A	GLY461
A	ALA462
A	GLY463
A	LYS464
A	THR465
A	SER466
A	GLN493

---

site_id	AC2
Number of Residues	9
Details	binding site for residue ATP C 701

Chain	Residue
C	THR460
C	GLY461
C	ALA462
C	GLY463
C	LYS464
C	THR465
C	SER466
C	GLN493
G	SER495

---

site_id	AC3
Number of Residues	13
Details	binding site for residue ATP E 701

Chain	Residue
A	PHE494
A	SER495
E	ASP443
E	THR460
E	GLY461
E	ALA462
E	GLY463
E	LYS464
E	THR465
E	SER466
E	GLN493
E	HOH804
E	HOH806

---

site_id	AC4
Number of Residues	14
Details	binding site for residue ATP G 701

Chain	Residue
C	PHE494
C	SER495
C	TRP496
G	ASP443
G	THR460
G	GLY461
G	ALA462
G	GLY463
G	LYS464
G	THR465
G	SER466
G	GLN493
G	HOH802
G	HOH818

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV

Chain	Residue	Details
A	LEU548-VAL562

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15528182","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15528182","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"22119790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---