6GH8

Crystal structure of GP1 domain of Lujo virus in complex with the first CUB domain of neuropilin-2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (D, B)	Glycoprotein	polymer	139	16021.9	2	UniProt (C5ILC1) Pfam (PF00798)	Lujo mammarenavirus
2	B, D (A, C)	Neuropilin-2	polymer	133	14914.5	2	UniProt (O60462) Pfam (PF00431)	Homo sapiens (Human)	Vascular endothelial cell growth factor 165 receptor 2
3	E, G, H (D, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
4	F, I (A, C)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
5	J, K, L, M (D, A, B, C)	water	water		18.0	41	Chemie (HOH)

Sequence modifications

D, B: 74 - 199 (UniProt: C5ILC1)

PDB	External Database	Details
Ala 61	-	expression tag
Asp 62	-	expression tag
Leu 63	-	expression tag
Gly 64	-	expression tag
Ser 65	-	expression tag
His 66	-	expression tag
His 67	-	expression tag
His 68	-	expression tag
His 69	-	expression tag
His 70	-	expression tag
His 71	-	expression tag
Gly 72	-	expression tag
Gly 73	-	expression tag

A, C: 27 - 146 (UniProt: O60462)

PDB	External Database	Details
Ala 22	-	expression tag
Asp 23	-	expression tag
Leu 24	-	expression tag
Gly 25	-	expression tag
Ser 26	-	expression tag
Arg 123	Lys 123	conflict
Gly 147	-	expression tag
Thr 148	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	61872.8
Non-Polymers*	Number of molecules	5
	Total formula weight	743.8
All*	Total formula weight	62616.6

*Water molecules are not included.