6GG6

Crystal structure of M2 PYK in complex with Serine.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Pyruvate kinase PKM	polymer	551	60204.3	8	UniProt (P14618) Pfam (PF00224) Pfam (PF02887)	Homo sapiens (Human)	Cytosolic thyroid hormone-binding protein,CTHBP,Opa-interacting protein 3,OIP-3,Pyruvate kinase 2/3,Pyruvate kinase muscle isozyme,Thyroid hormone-binding protein 1,THBP1,Tumor M2-PK,p58
2	CA, GA, I, KA, M... (F, G, A, H, B...)	POTASSIUM ION	non-polymer		39.1	8	Chemie (K)
3	DA, HA, J, LA, N... (F, G, A, H, B...)	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
4	AA, EA, IA, K, MA... (E, F, G, A, H...)	SERINE	non-polymer		105.1	8	Chemie (SER)
5	BA, FA, JA, L, NA... (E, F, G, A, H...)	PHOSPHATE ION	non-polymer		95.0	8	Chemie (PO4)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 531 (UniProt: P14618)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	481634.0
Non-Polymers*	Number of molecules	32
	Total formula weight	2107.7
All*	Total formula weight	483741.7

*Water molecules are not included.