6GG1

Structure of PROSS-edited human interleukin 24

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin-24	polymer	154	18065.5	1	UniProt (Q13007)	Homo sapiens (Human)	IL-24,Melanoma differentiation-associated gene 7 protein,MDA-7,Suppression of tumorigenicity 16 protein
2	B (A)	NICKEL (II) ION	non-polymer		58.7	1	Chemie (NI)
3	C, D (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	E (A)	water	water		18.0	206	Chemie (HOH)

Sequence modifications

A: 54 - 206 (UniProt: Q13007)

PDB	External Database	Details
Ala 53	-	expression tag
Arg 60	Gln 60	engineered mutation
Glu 62	Lys 62	engineered mutation
Glu 68	Lys 68	engineered mutation
Arg 77	Lys 77	engineered mutation
Leu 80	Met 80	engineered mutation
Asp 88	Ser 88	engineered mutation
Val 89	Ala 89	engineered mutation
Arg 93	Gln 93	engineered mutation
Ala 94	Gln 94	engineered mutation
Gln 111	Thr 111	engineered mutation
Arg 114	Glu 114	engineered mutation
Asp 118	Lys 118	engineered mutation
Lys 127	Arg 127	engineered mutation
Ala 129	Val 129	engineered mutation
Leu 131	Val 131	engineered mutation
Asp 150	Gln 150	engineered mutation
Cys 154	Ser 154	engineered mutation
Gln 157	Asn 157	engineered mutation
Asn 158	Glu 158	engineered mutation
Cys 160	Phe 160	engineered mutation
Ser 162	Ile 162	engineered mutation
Glu 164	Asp 164	engineered mutation
Glu 165	Ser 165	engineered mutation
Gln 172	Leu 172	engineered mutation
Gln 174	Arg 174	engineered mutation
Glu 178	Lys 178	engineered mutation
Ala 186	Leu 186	engineered mutation
Ile 193	Val 193	engineered mutation
Arg 198	Thr 198	engineered mutation
Gln 205	Lys 205	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	18065.5
Non-Polymers*	Number of molecules	3
	Total formula weight	250.8
All*	Total formula weight	18316.3

*Water molecules are not included.