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6GG1

Structure of PROSS-edited human interleukin 24

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006915biological_processapoptotic process
A0007165biological_processsignal transduction
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0030336biological_processnegative regulation of cell migration
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0071222biological_processcellular response to lipopolysaccharide
A0071353biological_processcellular response to interleukin-4
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue NI A 301
ChainResidue
AHIS125
ASER162
AHIS167
AHOH485
AHOH529

site_idAC2
Number of Residues12
Detailsbinding site for residues SO4 A 302 and SO4 A 303
ChainResidue
AARG168
AARG168
AARG175
AARG175
AHOH401
AHOH412
AHOH412
AHOH463
AHIS55
AHIS55
AARG60
AARG60

site_idAC3
Number of Residues12
Detailsbinding site for residues SO4 A 302 and SO4 A 303
ChainResidue
AHIS55
AHIS55
AARG60
AARG60
AARG168
AARG168
AARG175
AARG175
AHOH401
AHOH412
AHOH412
AHOH463

Functional Information from PROSITE/UniProt
site_idPS00520
Number of Residues21
DetailsINTERLEUKIN_10 Interleukin-10 family signature. SdaesCYlvhqLLrFYLdTVF
ChainResidueDetails
ASER101-PHE121

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN85
AASN99
AASN126

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23078624
ChainResidueDetails
ALYS122

218853

PDB entries from 2024-04-24

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