6GEI
TEAD4 (216-434);E263A+Y429F COMPLEXED WITH YAP PEPTIDE (60- 100);S94A AND MYRISTOATE (COVALENTLY BOUND TO LYS344, NOT CYS367!) AT 1.65A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Transcriptional enhancer factor TEF-3 | polymer | 219 | 25426.7 | 1 | UniProt (Q15561) Pfam (PF17725) In PDB | Homo sapiens (Human) | TEA domain family member 4,TEAD-4,Transcription factor 13-like 1,Transcription factor RTEF-1 |
2 | L | Transcriptional coactivator YAP1 | polymer | 42 | 4660.3 | 1 | UniProt (P46937) Pfam (PF15238) In PDB | Homo sapiens | Yes-associated protein 1,Protein yorkie homolog,Yes-associated protein YAP65 homolog |
3 | A | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
4 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
5 | water | water | 18.0 | 225 | Chemie (HOH) |
Sequence modifications
A: 216 - 434 (UniProt: Q15561)
L: 60 - 100 (UniProt: P46937)
PDB | External Database | Details |
---|---|---|
Ala 263 | Glu 263 | engineered mutation |
Phe 429 | Tyr 429 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ace 59 | - | expression tag |
Ala 94 | Ser 94 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 30087.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 323.3 | |
All* | Total formula weight | 30410.4 |