6GEI

TEAD4 (216-434);E263A+Y429F COMPLEXED WITH YAP PEPTIDE (60- 100);S94A AND MYRISTOATE (COVALENTLY BOUND TO LYS344, NOT CYS367!) AT 1.65A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Transcriptional enhancer factor TEF-3	polymer	219	25426.7	1	UniProt (Q15561) Pfam (PF17725) In PDB	Homo sapiens (Human)	TEA domain family member 4,TEAD-4,Transcription factor 13-like 1,Transcription factor RTEF-1
2	L	Transcriptional coactivator YAP1	polymer	42	4660.3	1	UniProt (P46937) Pfam (PF15238) In PDB	Homo sapiens	Yes-associated protein 1,Protein yorkie homolog,Yes-associated protein YAP65 homolog
3	A	MYRISTIC ACID	non-polymer		228.4	1	Chemie (MYR)
4	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
5		water	water		18.0	225	Chemie (HOH)

Sequence modifications

A: 216 - 434 (UniProt: Q15561)

PDB	External Database	Details
Ala 263	Glu 263	engineered mutation
Phe 429	Tyr 429	engineered mutation

L: 60 - 100 (UniProt: P46937)

PDB	External Database	Details
Ace 59	-	expression tag
Ala 94	Ser 94	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	30087.0
Non-Polymers*	Number of molecules	2
	Total formula weight	323.3
All*	Total formula weight	30410.4

*Water molecules are not included.