6GDG
Cryo-EM structure of the adenosine A2A receptor bound to a miniGs heterotrimer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | TrxA,Adenosine receptor A2a | polymer | 479 | 52909.8 | 1 | UniProt (Q14F07) UniProt (P29274) Pfam (PF00085) Pfam (PF00001) UniProt (by SIFTS) (P0AA25) In PDB | Escherichia coli | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | D | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 248 | 28907.7 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein,Adenylate cyclase-stimulating G alpha protein |
5 | E | nanobody Nb35 | polymer | 156 | 16926.1 | 1 | Lama glama (Llama) | ||
6 | A | N-ETHYL-5'-CARBOXAMIDO ADENOSINE | non-polymer | 308.3 | 1 | Chemie (NEC) |
Sequence modifications
A: -106 - 1 (UniProt: Q14F07)
A: 8 - 316 (UniProt: P29274)
C: 1 - 71 (UniProt: P59768)
D: 6 - 195 (UniProt: P63092)
D: 204 - 384 (UniProt: P63092)
PDB | External Database | Details |
---|---|---|
Met -162 | - | initiating methionine |
Leu -161 | - | expression tag |
Leu -160 | - | expression tag |
Val -159 | - | expression tag |
Asn -158 | - | expression tag |
Gln -157 | - | expression tag |
Ser -156 | - | expression tag |
His -155 | - | expression tag |
Gln -154 | - | expression tag |
Gly -153 | - | expression tag |
Phe -152 | - | expression tag |
Asn -151 | - | expression tag |
Lys -150 | - | expression tag |
Glu -149 | - | expression tag |
His -148 | - | expression tag |
Thr -147 | - | expression tag |
Ser -146 | - | expression tag |
Lys -145 | - | expression tag |
Met -144 | - | expression tag |
Val -143 | - | expression tag |
Ser -142 | - | expression tag |
Ala -141 | - | expression tag |
Ile -140 | - | expression tag |
Val -139 | - | expression tag |
Leu -138 | - | expression tag |
Tyr -137 | - | expression tag |
Val -136 | - | expression tag |
Leu -135 | - | expression tag |
Leu -134 | - | expression tag |
Ala -133 | - | expression tag |
Ala -132 | - | expression tag |
Ala -131 | - | expression tag |
Ala -130 | - | expression tag |
His -129 | - | expression tag |
Ser -128 | - | expression tag |
Ala -127 | - | expression tag |
Phe -126 | - | expression tag |
Ala -125 | - | expression tag |
Ala -124 | - | expression tag |
His -123 | - | expression tag |
His -122 | - | expression tag |
His -121 | - | expression tag |
His -120 | - | expression tag |
His -119 | - | expression tag |
His -118 | - | expression tag |
His -117 | - | expression tag |
His -116 | - | expression tag |
His -115 | - | expression tag |
His -114 | - | expression tag |
Glu -113 | - | expression tag |
Asn -112 | - | expression tag |
Leu -111 | - | expression tag |
Tyr -110 | - | expression tag |
Phe -109 | - | expression tag |
Gln -108 | - | expression tag |
Gly -107 | - | expression tag |
Ser -75 | Cys 68 | conflict |
Ser -72 | Cys 71 | conflict |
Ala -25 | Lys 118 | conflict |
Glu 2 | - | linker |
Ala 3 | - | linker |
Ala 4 | - | linker |
Ala 5 | - | linker |
Lys 6 | - | linker |
Ala 7 | - | linker |
PDB | External Database | Details |
---|---|---|
Ala 154 | Asn 154 | conflict |
PDB | External Database | Details |
---|---|---|
Ser 68 | Cys 68 | conflict |
PDB | External Database | Details |
---|---|---|
Asp 49 | Gly 49 | conflict |
Asn 50 | Glu 50 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 196 | - | linker |
Gly 197 | - | linker |
Ser 198 | - | linker |
Gly 199 | - | linker |
Gly 200 | - | linker |
Ser 201 | - | linker |
Gly 202 | - | linker |
Gly 203 | - | linker |
Asp 249 | Ala 249 | conflict |
Asp 252 | Ser 252 | conflict |
Ala 362 | Ile 372 | conflict |
Ile 365 | Val 375 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 143874.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 308.3 | |
All* | Total formula weight | 144182.6 |