6GAZ
Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. This file contains the 28S ribosomal subunit.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (BC) | Translation initiation factor IF-2, mitochondrial | polymer | 657 | 72811.2 | 1 | UniProt (P46199) Pfam (PF00009) Pfam (PF22042) Pfam (PF11987) | Homo sapiens (Human) | IF2(mt) |
| 2 | B (BT) | Mitochondrial ribosomal protein L19 | polymer | 292 | 33441.5 | 1 | UniProt (I3LNJ0) Pfam (PF01245) | Sus scrofa (Pig) | |
| 3 | C (AA) | 12S ribosomal RNA, mitochondrial | polymer | 962 | 308989.1 | 1 | GenBank (11055671) | Sus scrofa | |
| 4 | D (AB) | Mitochondrial ribosomal protein S2 | polymer | 289 | 31731.6 | 1 | UniProt (F1S001) Pfam (PF00318) | Sus scrofa (Pig) | |
| 5 | E (AC) | Mitochondrial ribosomal protein S24 | polymer | 167 | 18935.2 | 1 | UniProt (A0A287ANU4) Pfam (PF14955) | Sus scrofa (Pig) | |
| 6 | F (AE) | Mitochondrial ribosomal protein S5 | polymer | 430 | 48213.1 | 1 | UniProt (F1SU66) Pfam (PF21251) Pfam (PF00333) Pfam (PF03719) | Sus scrofa (Pig) | |
| 7 | G (AF) | Mitochondrial ribosomal protein S6 | polymer | 124 | 14283.7 | 1 | UniProt (I3LEJ9) | Sus scrofa (Pig) | Mitoribosomal protein bs6m,mrps6 |
| 8 | H (AG) | Mitochondrial ribosomal protein S7 | polymer | 242 | 28150.9 | 1 | UniProt (A0A286ZJ25) Pfam (PF00177) | Sus scrofa (Pig) | |
| 9 | I (AI) | Mitochondrial ribosomal protein S9 | polymer | 397 | 45604.6 | 1 | UniProt (I3LU08) Pfam (PF00380) | Sus scrofa (Pig) | |
| 10 | J (AJ) | Mitochondrial ribosomal protein S10 | polymer | 201 | 23192.8 | 1 | UniProt (F1RUU2) Pfam (PF00338) | Sus scrofa (Pig) | |
| 11 | K (AK) | Mitochondrial ribosomal protein S11 | polymer | 196 | 20841.9 | 1 | UniProt (A0A286ZJJ6) Pfam (PF00411) | Sus scrofa (Pig) | |
| 12 | L (AL) | Mitochondrial ribosomal protein S12 | polymer | 139 | 15257.1 | 1 | UniProt (A0A0M3KL52) | Sus scrofa (Pig) | Mitoribosomal protein us12m,mrps12 |
| 13 | M (AN) | Mitochondrial ribosomal protein S14 | polymer | 128 | 15120.7 | 1 | UniProt (A0A0M3KL53) Pfam (PF00253) | Sus scrofa (Pig) | Mitoribosomal protein us14m,mrps14 |
| 14 | N (AO) | Mitochondrial ribosomal protein S15 | polymer | 239 | 27411.4 | 1 | UniProt (A0A287BMP0) Pfam (PF00312) | Sus scrofa (Pig) | |
| 15 | O (AP) | bS16m, MRPS16 | polymer | 135 | 15182.7 | 1 | Sus scrofa | ||
| 16 | P (AQ) | Mitochondrial ribosomal protein S17 | polymer | 130 | 14452.0 | 1 | UniProt (F1RIU0) Pfam (PF00366) UniProt (by SIFTS) (A0A8D1UDM1) | Sus scrofa (Pig) | |
| 17 | Q (AR) | Mitochondrial ribosomal protein S18C | polymer | 143 | 16211.1 | 1 | UniProt (A0A0M3KL54) Pfam (PF01084) | Sus scrofa (Pig) | Mitoribosomal protein bs18m,mrps18c |
| 18 | R (AU) | Mitochondrial ribosomal protein S21 | polymer | 87 | 10682.5 | 1 | UniProt (A0A286ZNB3) Pfam (PF01165) | Sus scrofa (Pig) | |
| 19 | S (AV) | P-site fMet-tRNAMet, mitochondrial | polymer | 71 | 22664.5 | 1 | GenBank (1208989970) | Homo sapiens | |
| 20 | T (AX) | MT-CO3 mRNA, mitochondrial | polymer | 201 | 63946.1 | 1 | GenBank (1208989970) | Homo sapiens | |
| 21 | U (AZ) | unassigned secondary structure elements | polymer | 18 | 1297.4 | 1 | Sus scrofa | ||
| 22 | V (Aa) | Mitochondrial ribosomal protein S22 | polymer | 382 | 43234.6 | 1 | UniProt (A0A287AQT5) Pfam (PF10245) | Sus scrofa (Pig) | |
| 23 | W (Ab) | Mitochondrial ribosomal protein S23 | polymer | 190 | 21666.7 | 1 | UniProt (A0A287AEW3) Pfam (PF10484) | Sus scrofa (Pig) | |
| 24 | X (Ac) | Mitochondrial ribosomal protein S25 | polymer | 173 | 19954.2 | 1 | UniProt (A0A0M3KL55) Pfam (PF05047) | Sus scrofa (Pig) | Mitoribosomal protein ms25,mrps25 |
| 25 | Y (Ad) | Mitochondrial ribosomal protein S26 | polymer | 205 | 23637.9 | 1 | UniProt (A0A287AY01) | Sus scrofa (Pig) | |
| 26 | Z (Ae) | Mitochondrial ribosomal protein S27 | polymer | 390 | 45244.1 | 1 | UniProt (I3LK09) Pfam (PF10037) | Sus scrofa (Pig) | |
| 27 | AA (Af) | Mitoribosomal protein ms28, mrps28 | polymer | 188 | 21014.9 | 1 | UniProt (A0A0M3KL56) Pfam (PF10246) | Sus scrofa (Pig) | |
| 28 | BA (Ag) | Death associated protein 3 | polymer | 397 | 45582.4 | 1 | UniProt (I3LS10) Pfam (PF10236) UniProt (by SIFTS) (A0A8D1XNL0) | Sus scrofa (Pig) | |
| 29 | CA (Ah) | mS31, MRPS31 | polymer | 387 | 44092.0 | 1 | Sus scrofa (Pig) | ||
| 30 | DA (Ai) | Mitochondrial ribosomal protein S33 | polymer | 106 | 12544.6 | 1 | UniProt (F1S8G3) Pfam (PF08293) UniProt (by SIFTS) (A0A4X1V2H3) | Sus scrofa (Pig) | |
| 31 | EA (Aj) | Mitochondrial ribosomal protein S34 | polymer | 218 | 25843.8 | 1 | UniProt (F1RG19) | Sus scrofa (Pig) | |
| 32 | FA (Ak) | Mitochondrial ribosomal protein S35 | polymer | 325 | 37104.8 | 1 | UniProt (F1SG95) Pfam (PF10213) | Sus scrofa (Pig) | |
| 33 | GA (Am) | Mitochondrial ribosomal protein S37 | polymer | 118 | 13561.9 | 1 | UniProt (F1SU49) Pfam (PF06747) UniProt (by SIFTS) (A0A4X1SZV4) | Sus scrofa (Pig) | |
| 34 | HA (An) | Aurora kinase A interacting protein 1 | polymer | 199 | 22843.9 | 1 | UniProt (A0A287B3R8) Pfam (PF08213) UniProt (by SIFTS) (A0A8D2A802) | Sus scrofa (Pig) | |
| 35 | IA (Ao) | Mitochondrial ribosomal protein S39 | polymer | 692 | 76473.8 | 1 | UniProt (K7GKS8) Pfam (PF22330) Pfam (PF13812) | Sus scrofa (Pig) | |
| 36 | JA (Ap) | 28S ribosomal protein S18b, mitochondrial | polymer | 258 | 29220.5 | 1 | UniProt (Q767K8) Pfam (PF01084) | Sus scrofa (Pig) | S18mt-b,28S ribosomal protein S18-2,mitochondrial,MRP-S18-2 |
| 37 | KA (BC) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) PubChem (135398675) PubChem (135476260) PubChem (136073095) PubChem (136440011) PubChem (137176535) PubChem (169450542) | |||
| 38 | AB, AC, AD, AE, BB... (AA, BC, AB, AX, Ag...) | MAGNESIUM ION | non-polymer | 24.3 | 111 | Chemie (MG) PubChem (888) | |||
| 39 | MA (BC) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 40 | OA (AA) | SPERMINE | non-polymer | 202.3 | 1 | Chemie (SPM) PubChem (1103) | |||
| 41 | RE, UE, YE (AR, Ac, Ap) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 42 | SE (AV) | N-FORMYLMETHIONINE | non-polymer | 177.2 | 1 | Chemie (FME) PubChem (911) PubChem (439750) PubChem (6995182) | |||
| 43 | VE (Ag) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 44 | AF, ZE (Ag, BC) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
BC: 78 - 727 (UniProt: P46199)
AV: 1 - 68 (GenBank: 1208989970)
Ao: 1 - 692 (UniProt: K7GKS8)
Ao: 163 - 234 (PDB: 6GAZ)
Ao: 240 - 692 (PDB: 6GAZ)
| PDB | External Database | Details |
|---|---|---|
| Ser 71 | - | expression tag |
| Gly 72 | - | expression tag |
| Gly 73 | - | expression tag |
| Ser 74 | - | expression tag |
| Gly 75 | - | expression tag |
| Ser 76 | - | expression tag |
| Gly 77 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| C 69 | - | insertion |
| C 70 | - | insertion |
| A 71 | - | insertion |
Ao: 163 - 234 (PDB: 6GAZ)
Ao: 240 - 692 (PDB: 6GAZ)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 36 |
| Total formula weight | 1330441.3 | |
| Non-Polymers* | Number of molecules | 119 |
| Total formula weight | 4359.1 | |
| All* | Total formula weight | 1334800.4 |
