6GAZ
Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. This file contains the 28S ribosomal subunit.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (BC) | Translation initiation factor IF-2, mitochondrial | polymer | 657 | 72811.2 | 1 | UniProt (P46199) Pfam (PF00009) Pfam (PF22042) Pfam (PF11987) | Homo sapiens (Human) | IF2(mt) |
| 2 | B (BT) | Mitochondrial ribosomal protein L19 | polymer | 292 | 33441.5 | 1 | UniProt (I3LNJ0) Pfam (PF01245) | Sus scrofa (Pig) | |
| 3 | C (AA) | 12S ribosomal RNA, mitochondrial | polymer | 962 | 308989.1 | 1 | GenBank (11055671) | Sus scrofa | |
| 4 | D (AB) | Mitochondrial ribosomal protein S2 | polymer | 289 | 31731.6 | 1 | UniProt (F1S001) Pfam (PF00318) | Sus scrofa (Pig) | |
| 5 | E (AC) | Mitochondrial ribosomal protein S24 | polymer | 167 | 18935.2 | 1 | UniProt (A0A287ANU4) Pfam (PF14955) | Sus scrofa (Pig) | |
| 6 | F (AE) | Mitochondrial ribosomal protein S5 | polymer | 430 | 48213.1 | 1 | UniProt (F1SU66) Pfam (PF21251) Pfam (PF00333) Pfam (PF03719) | Sus scrofa (Pig) | |
| 7 | G (AF) | Mitochondrial ribosomal protein S6 | polymer | 124 | 14283.7 | 1 | UniProt (I3LEJ9) | Sus scrofa (Pig) | Mitoribosomal protein bs6m,mrps6 |
| 8 | H (AG) | Mitochondrial ribosomal protein S7 | polymer | 242 | 28150.9 | 1 | UniProt (A0A286ZJ25) Pfam (PF00177) | Sus scrofa (Pig) | |
| 9 | I (AI) | Mitochondrial ribosomal protein S9 | polymer | 397 | 45604.6 | 1 | UniProt (I3LU08) Pfam (PF00380) | Sus scrofa (Pig) | |
| 10 | J (AJ) | Mitochondrial ribosomal protein S10 | polymer | 201 | 23192.8 | 1 | UniProt (F1RUU2) Pfam (PF00338) | Sus scrofa (Pig) | |
| 11 | K (AK) | Mitochondrial ribosomal protein S11 | polymer | 196 | 20841.9 | 1 | UniProt (A0A286ZJJ6) Pfam (PF00411) | Sus scrofa (Pig) | |
| 12 | L (AL) | Mitochondrial ribosomal protein S12 | polymer | 139 | 15257.1 | 1 | UniProt (A0A0M3KL52) Pfam (PF00164) | Sus scrofa (Pig) | Mitoribosomal protein us12m,mrps12 |
| 13 | M (AN) | Mitochondrial ribosomal protein S14 | polymer | 128 | 15120.7 | 1 | UniProt (A0A0M3KL53) Pfam (PF00253) | Sus scrofa (Pig) | Mitoribosomal protein us14m,mrps14 |
| 14 | N (AO) | Mitochondrial ribosomal protein S15 | polymer | 239 | 27411.4 | 1 | UniProt (A0A287BMP0) Pfam (PF00312) | Sus scrofa (Pig) | |
| 15 | O (AP) | bS16m, MRPS16 | polymer | 135 | 15182.7 | 1 | Sus scrofa | ||
| 16 | P (AQ) | Mitochondrial ribosomal protein S17 | polymer | 130 | 14452.0 | 1 | UniProt (F1RIU0) Pfam (PF00366) UniProt (by SIFTS) (A0A8D1UDM1) | Sus scrofa (Pig) | |
| 17 | Q (AR) | Mitochondrial ribosomal protein S18C | polymer | 143 | 16211.1 | 1 | UniProt (A0A0M3KL54) Pfam (PF01084) | Sus scrofa (Pig) | Mitoribosomal protein bs18m,mrps18c |
| 18 | R (AU) | Mitochondrial ribosomal protein S21 | polymer | 87 | 10682.5 | 1 | UniProt (A0A286ZNB3) Pfam (PF01165) | Sus scrofa (Pig) | |
| 19 | S (AV) | P-site fMet-tRNAMet, mitochondrial | polymer | 71 | 22664.5 | 1 | GenBank (1208989970) | Homo sapiens | |
| 20 | T (AX) | MT-CO3 mRNA, mitochondrial | polymer | 201 | 63946.1 | 1 | GenBank (1208989970) | Homo sapiens | |
| 21 | U (AZ) | unassigned secondary structure elements | polymer | 18 | 1297.4 | 1 | Sus scrofa | ||
| 22 | V (Aa) | Mitochondrial ribosomal protein S22 | polymer | 382 | 43234.6 | 1 | UniProt (A0A287AQT5) Pfam (PF10245) | Sus scrofa (Pig) | |
| 23 | W (Ab) | Mitochondrial ribosomal protein S23 | polymer | 190 | 21666.7 | 1 | UniProt (A0A287AEW3) Pfam (PF10484) | Sus scrofa (Pig) | |
| 24 | X (Ac) | Mitochondrial ribosomal protein S25 | polymer | 173 | 19954.2 | 1 | UniProt (A0A0M3KL55) Pfam (PF05047) | Sus scrofa (Pig) | Mitoribosomal protein ms25,mrps25 |
| 25 | Y (Ad) | Mitochondrial ribosomal protein S26 | polymer | 205 | 23637.9 | 1 | UniProt (A0A287AY01) | Sus scrofa (Pig) | |
| 26 | Z (Ae) | Mitochondrial ribosomal protein S27 | polymer | 390 | 45244.1 | 1 | UniProt (I3LK09) Pfam (PF10037) | Sus scrofa (Pig) | |
| 27 | AA (Af) | Mitoribosomal protein ms28, mrps28 | polymer | 188 | 21014.9 | 1 | UniProt (A0A0M3KL56) Pfam (PF10246) | Sus scrofa (Pig) | |
| 28 | BA (Ag) | Death associated protein 3 | polymer | 397 | 45582.4 | 1 | UniProt (I3LS10) Pfam (PF10236) UniProt (by SIFTS) (A0A8D1XNL0) | Sus scrofa (Pig) | |
| 29 | CA (Ah) | mS31, MRPS31 | polymer | 387 | 44092.0 | 1 | Sus scrofa (Pig) | ||
| 30 | DA (Ai) | Mitochondrial ribosomal protein S33 | polymer | 106 | 12544.6 | 1 | UniProt (F1S8G3) Pfam (PF08293) UniProt (by SIFTS) (A0A4X1V2H3) | Sus scrofa (Pig) | |
| 31 | EA (Aj) | Mitochondrial ribosomal protein S34 | polymer | 218 | 25843.8 | 1 | UniProt (F1RG19) | Sus scrofa (Pig) | |
| 32 | FA (Ak) | Mitochondrial ribosomal protein S35 | polymer | 325 | 37104.8 | 1 | UniProt (F1SG95) Pfam (PF10213) | Sus scrofa (Pig) | |
| 33 | GA (Am) | Mitochondrial ribosomal protein S37 | polymer | 118 | 13561.9 | 1 | UniProt (F1SU49) Pfam (PF06747) UniProt (by SIFTS) (A0A4X1SZV4) | Sus scrofa (Pig) | |
| 34 | HA (An) | Aurora kinase A interacting protein 1 | polymer | 199 | 22843.9 | 1 | UniProt (A0A287B3R8) Pfam (PF08213) UniProt (by SIFTS) (A0A8D2A802) | Sus scrofa (Pig) | |
| 35 | IA (Ao) | Mitochondrial ribosomal protein S39 | polymer | 692 | 76473.8 | 1 | UniProt (K7GKS8) Pfam (PF22330) Pfam (PF13812) | Sus scrofa (Pig) | |
| 36 | JA (Ap) | 28S ribosomal protein S18b, mitochondrial | polymer | 258 | 29220.5 | 1 | UniProt (Q767K8) Pfam (PF01084) | Sus scrofa (Pig) | S18mt-b,28S ribosomal protein S18-2,mitochondrial,MRP-S18-2 |
| 37 | KA (BC) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
| 38 | AB, AC, AD, AE, BB... (AA, BC, AB, AX, Ag...) | MAGNESIUM ION | non-polymer | 24.3 | 111 | Chemie (MG) | |||
| 39 | MA (BC) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 40 | OA (AA) | SPERMINE | non-polymer | 202.3 | 1 | Chemie (SPM) | |||
| 41 | RE, UE, YE (AR, Ac, Ap) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 42 | SE (AV) | N-FORMYLMETHIONINE | non-polymer | 177.2 | 1 | Chemie (FME) | |||
| 43 | VE (Ag) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 44 | AF, ZE (Ag, BC) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
BC: 78 - 727 (UniProt: P46199)
AV: 1 - 68 (GenBank: 1208989970)
Ao: 1 - 692 (UniProt: K7GKS8)
Ao: 163 - 234 (PDB: 6GAZ)
Ao: 240 - 692 (PDB: 6GAZ)
| PDB | External Database | Details |
|---|---|---|
| Ser 71 | - | expression tag |
| Gly 72 | - | expression tag |
| Gly 73 | - | expression tag |
| Ser 74 | - | expression tag |
| Gly 75 | - | expression tag |
| Ser 76 | - | expression tag |
| Gly 77 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| C 69 | - | insertion |
| C 70 | - | insertion |
| A 71 | - | insertion |
Ao: 163 - 234 (PDB: 6GAZ)
Ao: 240 - 692 (PDB: 6GAZ)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 36 |
| Total formula weight | 1330441.3 | |
| Non-Polymers* | Number of molecules | 119 |
| Total formula weight | 4359.1 | |
| All* | Total formula weight | 1334800.4 |
