6G9I
Crystal structure of Ebolavirus glycoprotein in complex with clomipramine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Envelope glycoprotein,Envelope glycoprotein | polymer | 330 | 36302.7 | 1 | UniProt (Q05320) Pfam (PF01611) | Ebola virus - Mayinga Zaire 1976 | GP1,2,GP,GP1,2,GP |
| 2 | B (B) | Envelope glycoprotein,Envelope glycoprotein | polymer | 168 | 18922.3 | 1 | UniProt (Q05320) UniProt (M1E1E4) Pfam (PF22307) | Ebola virus - Mayinga Zaire 1976 | GP1,2,GP |
| 3 | C (C) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 4 | D, E, F, G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 5 | H, I, J, K (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | L (B) | 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE | non-polymer | 314.9 | 1 | Chemie (CXX) | |||
| 7 | M, N (A, B) | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
A: 32 - 310 (UniProt: Q05320)
A: 479 - 516 (UniProt: Q05320)
B: 502 - 632 (UniProt: Q05320)
B: 636 - 662 (UniProt: M1E1E4)
| PDB | External Database | Details |
|---|---|---|
| Glu 28 | - | expression tag |
| Thr 29 | - | expression tag |
| Gly 30 | - | expression tag |
| Arg 31 | - | expression tag |
| Ala 42 | Thr 42 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Unk 471 | - | linker |
| Unk 472 | - | linker |
| Unk 473 | - | linker |
| Unk 474 | - | linker |
| Unk 475 | - | linker |
| Unk 476 | - | linker |
| Unk 477 | - | linker |
| Ser 478 | - | linker |
| Thr 479 | Thr 464 | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 613 | His 613 | engineered mutation |
| Gly 633 | - | linker |
| Ser 634 | - | linker |
| Gly 635 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Thr 663 | - | expression tag |
| His 664 | - | expression tag |
| His 665 | - | expression tag |
| His 666 | - | expression tag |
| His 667 | - | expression tag |
| His 668 | - | expression tag |
| His 669 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 55225.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 748.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1568.1 | |
| All* | Total formula weight | 57541.8 |
