6G8F
Crystal structure of UTX complexed with GSK-J1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific demethylase 6A | polymer | 531 | 60264.4 | 1 | UniProt (O15550) Pfam (PF02373) Pfam (PF21322) Pfam (PF21326) | Homo sapiens (Human) | Histone demethylase UTX,Ubiquitously-transcribed TPR protein on the X chromosome,Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein |
| 2 | B (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid | non-polymer | 389.4 | 1 | Chemie (K0I) | |||
| 5 | E, F, G, H (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 6 | I (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | J (A) | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A: 876 - 1401 (UniProt: O15550)
| PDB | External Database | Details |
|---|---|---|
| Gly 871 | - | expression tag |
| Pro 872 | - | expression tag |
| Gly 873 | - | expression tag |
| Tyr 874 | - | expression tag |
| Gln 875 | - | expression tag |
| Asp 876 | Ser 878 | conflict |
| Asn 878 | - | insertion |
| Ser 879 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 60264.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 857.8 | |
| All* | Total formula weight | 61122.2 |
