6G1S
CryoEM structure of the MDA5-dsRNA filament with 87-degree helical twist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interferon-induced helicase C domain-containing protein 1 | polymer | 693 | 79703.3 | 1 | UniProt (Q8R5F7) Pfam (PF04851) Pfam (PF18119) Pfam (PF00271) Pfam (PF11648) | Mus musculus (Mouse) | Helicase with 2 CARD domains,Helicard,Interferon induced with helicase C domain protein 1,Melanoma differentiation-associated protein 5,MDA-5,RIG-I-like receptor 2,RLR-2 |
| 2 | B (X) | RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3') | polymer | 15 | 4767.9 | 1 | Pseudomonas phage phi6 | ||
| 3 | C (Y) | RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3') | polymer | 15 | 4807.9 | 1 | Pseudomonas phage phi6 | ||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 310 - 1020 (UniProt: Q8R5F7)
| PDB | External Database | Details |
|---|---|---|
| - | Asp 597 | deletion |
| - | Lys 598 | deletion |
| - | Ser 599 | deletion |
| - | Asp 600 | deletion |
| - | Asp 601 | deletion |
| - | Glu 602 | deletion |
| - | Ala 603 | deletion |
| - | Ser 604 | deletion |
| - | Ser 605 | deletion |
| - | Cys 606 | deletion |
| - | Asn 607 | deletion |
| - | Asp 608 | deletion |
| - | Gln 609 | deletion |
| - | Leu 610 | deletion |
| - | Lys 611 | deletion |
| - | Gly 612 | deletion |
| - | Asp 613 | deletion |
| - | Val 614 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 89279.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 89344.5 |
