6G0S
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated SIRT7 peptide (K272ac/K275ac)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 2 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
2 | D | NAD-dependent protein deacetylase sirtuin-7 | polymer | 11 | 1410.7 | 1 | UniProt (Q9NRC8) In PDB | Homo sapiens | Regulatory protein SIR2 homolog 7,SIR2-like protein 7 |
3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
4 | water | water | 18.0 | 245 | Chemie (HOH) |
Sequence modifications
A, B: 42 - 168 (UniProt: O60885)
D: 269 - 279 (UniProt: Q9NRC8)
PDB | External Database | Details |
---|---|---|
Met 43 | Thr 43 | conflict |
PDB | External Database | Details |
---|---|---|
Tyr 279 | Arg 279 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 31609.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 186.2 | |
All* | Total formula weight | 31795.6 |