6G0Q
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated GATA1 peptide (K312ac/K315ac)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1 |
| 2 | B (B) | Erythroid transcription factor | polymer | 11 | 1266.5 | 1 | UniProt (P15976) | Homo sapiens | Eryf1,GATA-binding factor 1,GF-1,NF-E1 DNA-binding protein |
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A: 42 - 168 (UniProt: O60885)
B: 309 - 319 (UniProt: P15976)
| PDB | External Database | Details |
|---|---|---|
| Met 43 | Thr 43 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Tyr 319 | Ser 319 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 16365.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 62.1 | |
| All* | Total formula weight | 16427.9 |
