6G0Q

Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated GATA1 peptide (K312ac/K315ac)

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 201

Chain	Residue
A	MET43
A	ASN54
A	ASN130
A	HOH328
A	HOH397
A	HOH398

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P17679

Chain	Residue	Details
B	SER310

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by CREBBP => ECO:0000250|UniProtKB:P17679

Chain	Residue	Details
B	ALY312

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P17679

Chain	Residue	Details
B	LYS314
B	ALY315

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