6FZJ
PPAR gamma mutant complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Peroxisome proliferator-activated receptor gamma | polymer | 275 | 31431.5 | 2 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (Human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 2 | C, D (C, D) | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 14 | 1523.9 | 2 | Homo sapiens | PPARGC-1-alpha,Ligand effect modulator 6 | |
| 3 | E, J (A, B) | (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid | non-polymer | 495.6 | 2 | Chemie (EDK) | |||
| 4 | F, K (A, B) | IODIDE ION | non-polymer | 126.9 | 2 | Chemie (IOD) | |||
| 5 | G, H, I, L (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 6 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 404 | Chemie (HOH) |
Sequence modifications
A, B: 231 - 505 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Ile 280 | Met 280 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 65910.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1386.8 | |
| All* | Total formula weight | 67297.4 |
