6FZF
PPAR mutant complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Peroxisome proliferator-activated receptor gamma | polymer | 279 | 31893.1 | 2 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (Human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 2 | C, D (C, D) | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 14 | 1523.9 | 2 | UniProt (Q9UBK2) | Homo sapiens | PPARGC-1-alpha,Ligand effect modulator 6 |
| 3 | E, F (A, B) | (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid | non-polymer | 495.6 | 2 | Chemie (EDK) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 567 | Chemie (HOH) |
Sequence modifications
A, B: 231 - 505 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Gly 227 | - | expression tag |
| Ser 228 | - | expression tag |
| His 229 | - | expression tag |
| Met 230 | - | expression tag |
| Met 475 | Thr 475 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 66833.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 991.1 | |
| All* | Total formula weight | 67825.0 |
