6FZF
PPAR mutant complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Peroxisome proliferator-activated receptor gamma | polymer | 279 | 31893.1 | 2 | UniProt (P37231) Pfam (PF00104) In PDB | Homo sapiens (Human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
2 | C, D | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 14 | 1523.9 | 2 | UniProt (Q9UBK2) In PDB | Homo sapiens | PPARGC-1-alpha,Ligand effect modulator 6 |
3 | A, B | (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid | non-polymer | 495.6 | 2 | Chemie (EDK) | |||
4 | water | water | 18.0 | 567 | Chemie (HOH) |
Sequence modifications
A, B: 231 - 505 (UniProt: P37231)
PDB | External Database | Details |
---|---|---|
Gly 227 | - | expression tag |
Ser 228 | - | expression tag |
His 229 | - | expression tag |
Met 230 | - | expression tag |
Met 475 | Thr 475 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 66833.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 991.1 | |
All* | Total formula weight | 67825.0 |