6FUW
Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution
Replaces: 6FBSEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cleavage and polyadenylation specificity factor subunit 1 | polymer | 1446 | 161346.5 | 1 | UniProt (Q10570) Pfam (PF10433) Pfam (PF03178) | Homo sapiens (Human) | Cleavage and polyadenylation specificity factor 160 kDa subunit,CPSF 160 kDa subunit |
| 2 | B (B) | pre-mRNA 3' end processing protein WDR33 | polymer | 413 | 47448.9 | 1 | UniProt (Q9C0J8) Pfam (PF00400) | Homo sapiens (Human) | WD repeat-containing protein 33,WD repeat-containing protein WDC146 |
| 3 | C (C) | Cleavage and polyadenylation specificity factor subunit 4 | polymer | 178 | 20422.9 | 1 | UniProt (O95639) Pfam (PF00642) Pfam (PF15663) | Homo sapiens (Human) | Cleavage and polyadenylation specificity factor 30 kDa subunit,CPSF 30 kDa subunit,NS1 effector domain-binding protein 1,Neb-1,No arches homolog |
| 4 | D (D) | RNA (5'-R(P*AP*AP*UP*AP*AP*AP*GP*G)-3') | polymer | 10 | 3232.0 | 1 | unidentified adenovirus | ||
| 5 | E, F, G (C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence modifications
A: 1 - 1443 (UniProt: Q10570)
B: 1 - 410 (UniProt: Q9C0J8)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 232450.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 232646.5 |
