6FUG

Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Complement factor D	polymer	232	24739.1	6	UniProt (P00746) Pfam (PF00089)	Homo sapiens (Human)	Adipsin,C3 convertase activator,Properdin factor D
2	G, H, I, J, K... (A, B, C, D, E...)	3-[[3-[[3-(aminomethyl)phenyl]amino]-1~{H}-pyrazolo[3,4-d]pyrimidin-4-yl]amino]phenol	non-polymer		347.4	6	Chemie (E85)
3	M, N, O, P, Q... (A, B, C, D, E...)	water	water		18.0	285	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 16 - 243 (UniProt: P00746)

PDB	External Database	Details
Ser 244	-	expression tag
Ala 245	-	expression tag
Ala 246	-	expression tag
Ala 247	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	148434.7
Non-Polymers*	Number of molecules	6
	Total formula weight	2084.2
All*	Total formula weight	150519.0

*Water molecules are not included.