Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6FUG

Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0006956	biological_process	complement activation
A	0006957	biological_process	complement activation, alternative pathway
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0009617	biological_process	response to bacterium
A	0016787	molecular_function	hydrolase activity
A	0031093	cellular_component	platelet alpha granule lumen
A	0031638	biological_process	zymogen activation
A	0034774	cellular_component	secretory granule lumen
A	0045087	biological_process	innate immune response
A	0051604	biological_process	protein maturation
A	0070062	cellular_component	extracellular exosome
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0002376	biological_process	immune system process
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006508	biological_process	proteolysis
B	0006956	biological_process	complement activation
B	0006957	biological_process	complement activation, alternative pathway
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0009617	biological_process	response to bacterium
B	0016787	molecular_function	hydrolase activity
B	0031093	cellular_component	platelet alpha granule lumen
B	0031638	biological_process	zymogen activation
B	0034774	cellular_component	secretory granule lumen
B	0045087	biological_process	innate immune response
B	0051604	biological_process	protein maturation
B	0070062	cellular_component	extracellular exosome
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0002376	biological_process	immune system process
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006508	biological_process	proteolysis
C	0006956	biological_process	complement activation
C	0006957	biological_process	complement activation, alternative pathway
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0009617	biological_process	response to bacterium
C	0016787	molecular_function	hydrolase activity
C	0031093	cellular_component	platelet alpha granule lumen
C	0031638	biological_process	zymogen activation
C	0034774	cellular_component	secretory granule lumen
C	0045087	biological_process	innate immune response
C	0051604	biological_process	protein maturation
C	0070062	cellular_component	extracellular exosome
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0002376	biological_process	immune system process
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006508	biological_process	proteolysis
D	0006956	biological_process	complement activation
D	0006957	biological_process	complement activation, alternative pathway
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0009617	biological_process	response to bacterium
D	0016787	molecular_function	hydrolase activity
D	0031093	cellular_component	platelet alpha granule lumen
D	0031638	biological_process	zymogen activation
D	0034774	cellular_component	secretory granule lumen
D	0045087	biological_process	innate immune response
D	0051604	biological_process	protein maturation
D	0070062	cellular_component	extracellular exosome
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0002376	biological_process	immune system process
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006508	biological_process	proteolysis
E	0006956	biological_process	complement activation
E	0006957	biological_process	complement activation, alternative pathway
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0009617	biological_process	response to bacterium
E	0016787	molecular_function	hydrolase activity
E	0031093	cellular_component	platelet alpha granule lumen
E	0031638	biological_process	zymogen activation
E	0034774	cellular_component	secretory granule lumen
E	0045087	biological_process	innate immune response
E	0051604	biological_process	protein maturation
E	0070062	cellular_component	extracellular exosome
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0002376	biological_process	immune system process
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006508	biological_process	proteolysis
F	0006956	biological_process	complement activation
F	0006957	biological_process	complement activation, alternative pathway
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0009617	biological_process	response to bacterium
F	0016787	molecular_function	hydrolase activity
F	0031093	cellular_component	platelet alpha granule lumen
F	0031638	biological_process	zymogen activation
F	0034774	cellular_component	secretory granule lumen
F	0045087	biological_process	innate immune response
F	0051604	biological_process	protein maturation
F	0070062	cellular_component	extracellular exosome
F	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue E85 A 301

Chain	Residue
A	HIS146
A	CYS220
A	ASP189
A	SER190
A	CYS191
A	LYS192
A	SER195
A	VAL213
A	ARG218
A	VAL219

site_id	AC2
Number of Residues	11
Details	binding site for residue E85 B 301

Chain	Residue
B	HIS146
B	ASP189
B	SER190
B	CYS191
B	LYS192
B	SER195
B	ARG218
B	VAL219
B	CYS220
D	ALA147
D	HOH410

site_id	AC3
Number of Residues	9
Details	binding site for residue E85 C 301

Chain	Residue
C	HIS146
C	ASP189
C	SER190
C	CYS191
C	LYS192
C	SER195
C	ARG218
C	VAL219
C	CYS220

site_id	AC4
Number of Residues	12
Details	binding site for residue E85 D 301

Chain	Residue
D	ILE143
D	HIS146
D	ASP189
D	SER190
D	CYS191
D	LYS192
D	SER195
D	VAL213
D	THR214
D	ARG218
D	VAL219
D	CYS220

site_id	AC5
Number of Residues	9
Details	binding site for residue E85 E 301

Chain	Residue
E	HIS146
E	ASP189
E	SER190
E	CYS191
E	LYS192
E	SER195
E	VAL219
E	CYS220
E	HOH404

site_id	AC6
Number of Residues	12
Details	binding site for residue E85 F 301

Chain	Residue
E	PRO96
F	ILE143
F	HIS146
F	ASP189
F	SER190
F	CYS191
F	LYS192
F	SER195
F	VAL213
F	THR214
F	VAL219
F	CYS220

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC

Chain	Residue	Details
A	LEU53-CYS58

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV

Chain	Residue	Details
A	ASP189-VAL200

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9753554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21205667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22362762","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)