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6FUG

Complement factor D in complex with the inhibitor 3-((3-((3-(aminomethyl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)phenol

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0006956biological_processcomplement activation
A0006957biological_processcomplement activation, alternative pathway
A0008236molecular_functionserine-type peptidase activity
A0009617biological_processresponse to bacterium
A0031093cellular_componentplatelet alpha granule lumen
A0034774cellular_componentsecretory granule lumen
A0070062cellular_componentextracellular exosome
A1904813cellular_componentficolin-1-rich granule lumen
B0004252molecular_functionserine-type endopeptidase activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006508biological_processproteolysis
B0006956biological_processcomplement activation
B0006957biological_processcomplement activation, alternative pathway
B0008236molecular_functionserine-type peptidase activity
B0009617biological_processresponse to bacterium
B0031093cellular_componentplatelet alpha granule lumen
B0034774cellular_componentsecretory granule lumen
B0070062cellular_componentextracellular exosome
B1904813cellular_componentficolin-1-rich granule lumen
C0004252molecular_functionserine-type endopeptidase activity
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006508biological_processproteolysis
C0006956biological_processcomplement activation
C0006957biological_processcomplement activation, alternative pathway
C0008236molecular_functionserine-type peptidase activity
C0009617biological_processresponse to bacterium
C0031093cellular_componentplatelet alpha granule lumen
C0034774cellular_componentsecretory granule lumen
C0070062cellular_componentextracellular exosome
C1904813cellular_componentficolin-1-rich granule lumen
D0004252molecular_functionserine-type endopeptidase activity
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006508biological_processproteolysis
D0006956biological_processcomplement activation
D0006957biological_processcomplement activation, alternative pathway
D0008236molecular_functionserine-type peptidase activity
D0009617biological_processresponse to bacterium
D0031093cellular_componentplatelet alpha granule lumen
D0034774cellular_componentsecretory granule lumen
D0070062cellular_componentextracellular exosome
D1904813cellular_componentficolin-1-rich granule lumen
E0004252molecular_functionserine-type endopeptidase activity
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0006508biological_processproteolysis
E0006956biological_processcomplement activation
E0006957biological_processcomplement activation, alternative pathway
E0008236molecular_functionserine-type peptidase activity
E0009617biological_processresponse to bacterium
E0031093cellular_componentplatelet alpha granule lumen
E0034774cellular_componentsecretory granule lumen
E0070062cellular_componentextracellular exosome
E1904813cellular_componentficolin-1-rich granule lumen
F0004252molecular_functionserine-type endopeptidase activity
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0006508biological_processproteolysis
F0006956biological_processcomplement activation
F0006957biological_processcomplement activation, alternative pathway
F0008236molecular_functionserine-type peptidase activity
F0009617biological_processresponse to bacterium
F0031093cellular_componentplatelet alpha granule lumen
F0034774cellular_componentsecretory granule lumen
F0070062cellular_componentextracellular exosome
F1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue E85 A 301
ChainResidue
AHIS146
ACYS220
AASP189
ASER190
ACYS191
ALYS192
ASER195
AVAL213
AARG218
AVAL219

site_idAC2
Number of Residues11
Detailsbinding site for residue E85 B 301
ChainResidue
BHIS146
BASP189
BSER190
BCYS191
BLYS192
BSER195
BARG218
BVAL219
BCYS220
DALA147
DHOH410

site_idAC3
Number of Residues9
Detailsbinding site for residue E85 C 301
ChainResidue
CHIS146
CASP189
CSER190
CCYS191
CLYS192
CSER195
CARG218
CVAL219
CCYS220

site_idAC4
Number of Residues12
Detailsbinding site for residue E85 D 301
ChainResidue
DILE143
DHIS146
DASP189
DSER190
DCYS191
DLYS192
DSER195
DVAL213
DTHR214
DARG218
DVAL219
DCYS220

site_idAC5
Number of Residues9
Detailsbinding site for residue E85 E 301
ChainResidue
EHIS146
EASP189
ESER190
ECYS191
ELYS192
ESER195
EVAL219
ECYS220
EHOH404

site_idAC6
Number of Residues12
Detailsbinding site for residue E85 F 301
ChainResidue
EPRO96
FILE143
FHIS146
FASP189
FSER190
FCYS191
FLYS192
FSER195
FVAL213
FTHR214
FVAL219
FCYS220

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC
ChainResidueDetails
ALEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
DHIS57
DASP102
DSER195
EHIS57
EASP102
ESER195
FHIS57
FASP102
FSER195
AASP102
ASER195
BHIS57
BASP102
BSER195
CHIS57
CASP102
CSER195

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PDB entries from 2024-07-10

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