6FU1
Crystal structure of Schistosoma mansoni HDAC8 complexed with a n-alkyl hydroxamate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Histone deacetylase | polymer | 446 | 50444.9 | 4 | UniProt (A5H660) Pfam (PF00850) In PDB | Schistosoma mansoni (Blood fluke) | |
2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
3 | A, B, C, D | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
4 | A, B | ~{N}-[(3~{S})-1-(4-chlorophenyl)-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-~{N}-oxidanyl-hexanamide | non-polymer | 338.8 | 4 | Chemie (E7Q) | |||
5 | A, B, C | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
6 | water | water | 18.0 | 599 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 440 (UniProt: A5H660)
PDB | External Database | Details |
---|---|---|
Gly 441 | - | expression tag |
Ser 442 | - | expression tag |
Leu 443 | - | expression tag |
Val 444 | - | expression tag |
Pro 445 | - | expression tag |
Arg 446 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 201779.5 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 2205.8 | |
All* | Total formula weight | 203985.3 |