6FU1
Crystal structure of Schistosoma mansoni HDAC8 complexed with a n-alkyl hydroxamate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0004407 | molecular_function | histone deacetylase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0004407 | molecular_function | histone deacetylase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| C | 0004407 | molecular_function | histone deacetylase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006338 | biological_process | chromatin remodeling |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| D | 0004407 | molecular_function | histone deacetylase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006338 | biological_process | chromatin remodeling |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | ASP186 |
| A | HIS188 |
| A | ASP285 |
| A | E7Q504 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue K A 502 |
| Chain | Residue |
| A | ASP184 |
| A | ASP186 |
| A | HIS188 |
| A | SER207 |
| A | VAL208 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue K A 503 |
| Chain | Residue |
| A | PHE197 |
| A | SER200 |
| A | VAL203 |
| A | SER243 |
| A | HOH694 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue E7Q A 504 |
| Chain | Residue |
| A | ASP100 |
| A | GLY139 |
| A | TRP140 |
| A | HIS141 |
| A | HIS142 |
| A | GLY150 |
| A | PHE151 |
| A | CYS152 |
| A | ASP186 |
| A | HIS188 |
| A | PHE216 |
| A | ASP285 |
| A | HIS292 |
| A | GLY338 |
| A | GLY339 |
| A | TYR341 |
| A | ZN501 |
| B | ASP50 |
| B | HOH736 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | HIS189 |
| A | GLU194 |
| A | THR219 |
| A | GLY220 |
| A | THR221 |
| A | ASN223 |
| A | PHE233 |
| A | LEU234 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue E7Q A 506 |
| Chain | Residue |
| A | GLY238 |
| A | ARG239 |
| C | PHE300 |
| C | PRO302 |
| C | CYS314 |
| C | SER315 |
| C | ASP388 |
| C | PRO393 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | ASP186 |
| B | HIS188 |
| B | ASP285 |
| B | E7Q504 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue K B 502 |
| Chain | Residue |
| B | ASP184 |
| B | ASP186 |
| B | HIS188 |
| B | SER207 |
| B | VAL208 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue K B 503 |
| Chain | Residue |
| B | PHE197 |
| B | SER200 |
| B | VAL203 |
| B | SER243 |
| B | HOH701 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for residue E7Q B 504 |
| Chain | Residue |
| B | PHE21 |
| B | TRP140 |
| B | HIS141 |
| B | HIS142 |
| B | GLY150 |
| B | PHE151 |
| B | CYS152 |
| B | ASP186 |
| B | HIS188 |
| B | ASP285 |
| B | GLY339 |
| B | TYR341 |
| B | ZN501 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue E7Q B 505 |
| Chain | Residue |
| B | PHE300 |
| B | PRO302 |
| B | CYS314 |
| B | SER315 |
| B | ASP388 |
| B | PRO393 |
| D | GLY238 |
| D | ARG239 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 506 |
| Chain | Residue |
| B | HIS189 |
| B | GLU194 |
| B | GLY220 |
| B | THR221 |
| B | PHE233 |
| B | LEU234 |
| B | ASN246 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN C 501 |
| Chain | Residue |
| C | ASP186 |
| C | HIS188 |
| C | ASP285 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue K C 502 |
| Chain | Residue |
| C | ASP184 |
| C | ASP186 |
| C | HIS188 |
| C | SER207 |
| C | VAL208 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue K C 503 |
| Chain | Residue |
| C | PHE197 |
| C | SER200 |
| C | VAL203 |
| C | SER243 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| C | HIS189 |
| C | GLU194 |
| C | GLY220 |
| C | THR221 |
| C | PHE233 |
| C | LEU234 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue ZN D 501 |
| Chain | Residue |
| D | ASP186 |
| D | HIS188 |
| D | ASP285 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue K D 502 |
| Chain | Residue |
| D | ASP184 |
| D | ASP186 |
| D | HIS188 |
| D | SER207 |
| D | VAL208 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue K D 503 |
| Chain | Residue |
| D | PHE197 |
| D | SER200 |
| D | VAL203 |
| D | SER243 |
| D | HOH699 |
