6FS2
MCL1 in complex with indole acid ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 154 | 17586.9 | 2 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | C, D, E, F (A, B) | 7-(2-methylphenyl)-3-[3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propyl]-1~{H}-indole-2-carboxylic acid | non-polymer | 439.5 | 4 | Chemie (E4K) | |||
| 3 | G, H (A, B) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A, B: 174 - 325 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Asp 172 | - | expression tag |
| Asp 173 | - | expression tag |
| Ser 193 | Ala 193 | conflict |
| Leu 199 | Met 199 | conflict |
| Glu 201 | Arg 201 | conflict |
| Ala 202 | Ser 202 | conflict |
| Ala 205 | Thr 205 | conflict |
| Gly 206 | Ser 206 | conflict |
| Arg 208 | Lys 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35173.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1758.2 | |
| All* | Total formula weight | 36932.1 |
