6FO6

CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	E, R	Cytochrome b-c1 complex subunit Rieske, mitochondrial	polymer	274	29586.8	2	UniProt (P13272) Pfam (PF00355) Pfam (PF09165) Pfam (PF02921) In PDB	Bos taurus (Bovine)	Complex III subunit 5,Cytochrome b-c1 complex subunit 5,Rieske iron-sulfur protein,RISP,Rieske protein UQCRFS1,Ubiquinol-cytochrome c reductase iron-sulfur subunit
2	A, N	Cytochrome b-c1 complex subunit 1, mitochondrial	polymer	480	52796.4	2	UniProt (P31800) Pfam (PF00675) Pfam (PF05193) In PDB	Bos taurus (Bovine)	Complex III subunit 1,Core protein I,Ubiquinol-cytochrome-c reductase complex core protein 1
3	B, O	Cytochrome b-c1 complex subunit 2, mitochondrial	polymer	453	48203.4	2	UniProt (P23004) Pfam (PF00675) Pfam (PF05193) In PDB	Bos taurus (Bovine)	Complex III subunit 2,Core protein II,Ubiquinol-cytochrome-c reductase complex core protein 2
4	C, P	Cytochrome b	polymer	379	42620.3	2	UniProt (P00157) Pfam (PF00033) Pfam (PF00032) In PDB	Bos taurus (Bovine)	Complex III subunit 3,Complex III subunit III,Cytochrome b-c1 complex subunit 3,Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
5	D, Q	Cytochrome c1, heme protein, mitochondrial	polymer	325	35343.8	2	UniProt (P00125) Pfam (PF02167) In PDB	Bos taurus (Bovine)	Complex III subunit 4,Complex III subunit IV,Cytochrome b-c1 complex subunit 4,Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit,Cytochrome c-1
6	F, S	Cytochrome b-c1 complex subunit 7	polymer	111	13502.4	2	UniProt (P00129) Pfam (PF02271) In PDB	Bos taurus (Bovine)	Complex III subunit 7,Complex III subunit VII,QP-C,Ubiquinol-cytochrome c reductase complex 14 kDa protein
7	G, T	Cytochrome b-c1 complex subunit 8	polymer	82	9737.2	2	UniProt (P13271) Pfam (PF02939) In PDB	Bos taurus (Bovine)	Complex III subunit 8,Complex III subunit VIII,Ubiquinol-cytochrome c reductase complex 9.5 kDa protein,Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
8	H, U	Cytochrome b-c1 complex subunit 6, mitochondrial	polymer	91	10638.7	2	UniProt (P00126) Pfam (PF02320) In PDB	Bos taurus (Bovine)	Complex III subunit 6,Complex III subunit VIII,Cytochrome c1 non-heme 11 kDa protein,Mitochondrial hinge protein,Ubiquinol-cytochrome c reductase complex 11 kDa protein
9	J, W	Cytochrome b-c1 complex subunit 9	polymer	64	7469.6	2	UniProt (P00130) Pfam (PF05365) In PDB	Bos taurus (Bovine)	Complex III subunit 9,Complex III subunit X,Cytochrome c1 non-heme 7 kDa protein,Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
10	C, P	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	4	Chemie (HEM)
11	C, P	7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol	non-polymer		426.4	2	Chemie (DY2)
12	D, Q	HEME C	non-polymer		618.5	2	Chemie (HEC)

Sequence modifications

F, S: 0 - 110 (UniProt: P00129)

PDB	External Database	Details
Asp 56	Asn 57	conflict

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	499797.5
Non-Polymers*	Number of molecules	8
	Total formula weight	4555.7
All*	Total formula weight	504353.3

*Water molecules are not included.