6FNE
Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | IQ motif and SEC7 domain-containing protein 1 | polymer | 405 | 47392.6 | 2 | UniProt (Q6DN90) Pfam (PF01369) Pfam (PF16453) In PDB | Homo sapiens (Human) | ADP-ribosylation factors guanine nucleotide-exchange protein 100,ADP-ribosylation factors guanine nucleotide-exchange protein 2,Brefeldin-resistant Arf-GEF 2 protein,BRAG2 |
2 | A | (2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one | non-polymer | 275.2 | 1 | Chemie (DY5) | |||
3 | A | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 1 | Chemie (2PE) | |||
4 | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A, B: 390 - 763 (UniProt: Q6DN90)
PDB | External Database | Details |
---|---|---|
Met 359 | - | initiating methionine |
Ser 360 | - | expression tag |
Tyr 361 | - | expression tag |
Tyr 362 | - | expression tag |
His 363 | - | expression tag |
His 364 | - | expression tag |
His 365 | - | expression tag |
His 366 | - | expression tag |
His 367 | - | expression tag |
His 368 | - | expression tag |
Asp 369 | - | expression tag |
Tyr 370 | - | expression tag |
Asp 371 | - | expression tag |
Ile 372 | - | expression tag |
Pro 373 | - | expression tag |
Thr 374 | - | expression tag |
Thr 375 | - | expression tag |
Glu 376 | - | expression tag |
Asn 377 | - | expression tag |
Leu 378 | - | expression tag |
Tyr 379 | - | expression tag |
Phe 380 | - | expression tag |
Gln 381 | - | expression tag |
Gly 382 | - | expression tag |
Ala 383 | - | expression tag |
Met 384 | - | expression tag |
Gly 385 | - | expression tag |
Ser 386 | - | expression tag |
Glu 387 | - | expression tag |
Phe 388 | - | expression tag |
Met 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 94785.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 689.7 | |
All* | Total formula weight | 95474.8 |