6FNE

Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	IQ motif and SEC7 domain-containing protein 1	polymer	405	47392.6	2	UniProt (Q6DN90) Pfam (PF01369) Pfam (PF16453)	Homo sapiens (Human)	ADP-ribosylation factors guanine nucleotide-exchange protein 100,ADP-ribosylation factors guanine nucleotide-exchange protein 2,Brefeldin-resistant Arf-GEF 2 protein,BRAG2
2	C (A)	(2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one	non-polymer		275.2	1	Chemie (DY5)
3	D (A)	NONAETHYLENE GLYCOL	non-polymer		414.5	1	Chemie (2PE)
4	E, F (A, B)	water	water		18.0	18	Chemie (HOH)

Sequence modifications

A, B: 390 - 763 (UniProt: Q6DN90)

PDB	External Database	Details
Met 359	-	initiating methionine
Ser 360	-	expression tag
Tyr 361	-	expression tag
Tyr 362	-	expression tag
His 363	-	expression tag
His 364	-	expression tag
His 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag
Asp 369	-	expression tag
Tyr 370	-	expression tag
Asp 371	-	expression tag
Ile 372	-	expression tag
Pro 373	-	expression tag
Thr 374	-	expression tag
Thr 375	-	expression tag
Glu 376	-	expression tag
Asn 377	-	expression tag
Leu 378	-	expression tag
Tyr 379	-	expression tag
Phe 380	-	expression tag
Gln 381	-	expression tag
Gly 382	-	expression tag
Ala 383	-	expression tag
Met 384	-	expression tag
Gly 385	-	expression tag
Ser 386	-	expression tag
Glu 387	-	expression tag
Phe 388	-	expression tag
Met 389	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	94785.1
Non-Polymers*	Number of molecules	2
	Total formula weight	689.7
All*	Total formula weight	95474.8

*Water molecules are not included.