6FNE
Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| A | 0032012 | biological_process | regulation of ARF protein signal transduction |
| B | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| B | 0032012 | biological_process | regulation of ARF protein signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue DY5 A 801 |
| Chain | Residue |
| A | HIS652 |
| A | ARG654 |
| A | LYS667 |
| A | ARG681 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue 2PE A 802 |
| Chain | Residue |
| A | ASP734 |
| A | LYS403 |
| A | ARG407 |
| A | LYS445 |
| A | ARG630 |
| A | VAL632 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER390 | |
| B | SER390 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER393 | |
| B | SER393 |
