6FIO
DDR1, 2-[1'-(1H-indazole-5-carbonyl)-4-methyl-2-oxospiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide, 1.990A, P6522, Rfree=27.7%
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epithelial discoidin domain-containing receptor 1 | polymer | 321 | 36502.9 | 1 | UniProt (Q08345) Pfam (PF07714) In PDB | Homo sapiens (Human) | Epithelial discoidin domain receptor 1,CD167 antigen-like family member A,Cell adhesion kinase,Discoidin receptor tyrosine kinase,HGK2,Mammary carcinoma kinase 10,MCK-10,Protein-tyrosine kinase 3A,Protein-tyrosine kinase RTK-6,TRK E,Tyrosine kinase DDR,Tyrosine-protein kinase CAK |
2 | A | 2-[1'-(1~{H}-indazol-5-ylcarbonyl)-4-methyl-2-oxidanylidene-spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | non-polymer | 499.5 | 1 | Chemie (DJH) | |||
3 | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A: 593 - 907 (UniProt: Q08345)
PDB | External Database | Details |
---|---|---|
His 908 | - | expression tag |
His 909 | - | expression tag |
His 910 | - | expression tag |
His 911 | - | expression tag |
His 912 | - | expression tag |
His 913 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36502.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 499.5 | |
All* | Total formula weight | 37002.3 |