6FIN

DDR1, 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, 1.670A, P1211, Rfree=22.8%

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Epithelial discoidin domain-containing receptor 1	polymer	321	36502.9	1	UniProt (Q08345) Pfam (PF07714) In PDB	Homo sapiens (Human)	Epithelial discoidin domain receptor 1,CD167 antigen-like family member A,Cell adhesion kinase,Discoidin receptor tyrosine kinase,HGK2,Mammary carcinoma kinase 10,MCK-10,Protein-tyrosine kinase 3A,Protein-tyrosine kinase RTK-6,TRK E,Tyrosine kinase DDR,Tyrosine-protein kinase CAK
2	A	IODIDE ION	non-polymer		126.9	8	Chemie (IOD)
3	A	3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1~{H}-indazol-5-ylcarbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one	non-polymer		497.5	1	Chemie (DJQ)
4		water	water		18.0	196	Chemie (HOH)

Sequence modifications

A: 593 - 913 (UniProt: Q08345)

PDB	External Database	Details
-	Gly 730	deletion
-	Gln 731	deletion
-	Ala 732	deletion
-	Ala 733	deletion
-	Gln 734	deletion
-	Gly 735	deletion
His 914	-	expression tag
His 915	-	expression tag
His 916	-	expression tag
His 917	-	expression tag
His 918	-	expression tag
His 919	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36502.9
Non-Polymers*	Number of molecules	9
	Total formula weight	1512.8
All*	Total formula weight	38015.6

*Water molecules are not included.