6FIL

DDR1, 2-[8-(1H-indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-methylacetamide, 1.730A, P212121, Rfree=24.5%

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Epithelial discoidin domain-containing receptor 1	polymer	321	36502.9	1	UniProt (Q08345) Pfam (PF07714) In PDB	Homo sapiens (Human)	Epithelial discoidin domain receptor 1,CD167 antigen-like family member A,Cell adhesion kinase,Discoidin receptor tyrosine kinase,HGK2,Mammary carcinoma kinase 10,MCK-10,Protein-tyrosine kinase 3A,Protein-tyrosine kinase RTK-6,TRK E,Tyrosine kinase DDR,Tyrosine-protein kinase CAK
2	A	2-[8-(2~{H}-indazol-5-ylcarbonyl)-4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-~{N}-methyl-ethanamide	non-polymer		446.5	1	Chemie (D6W)
3	A	IODIDE ION	non-polymer		126.9	1	Chemie (IOD)
4		water	water		18.0	252	Chemie (HOH)

Sequence modifications

A: 593 - 907 (UniProt: Q08345)

PDB	External Database	Details
-	Gly 711	deletion
-	Gln 712	deletion
-	Ala 713	deletion
-	Ala 714	deletion
-	Gln 715	deletion
-	Gly 716	deletion
His 908	-	expression tag
His 909	-	expression tag
His 910	-	expression tag
His 911	-	expression tag
His 912	-	expression tag
His 913	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36502.9
Non-Polymers*	Number of molecules	2
	Total formula weight	573.4
All*	Total formula weight	37076.3

*Water molecules are not included.