6FEW
DDR1, 2-[8-(1H-indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-methylacetamide, 1.440A, P1211, Rfree=24.1%
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epithelial discoidin domain-containing receptor 1 | polymer | 321 | 36502.9 | 1 | UniProt (Q08345) Pfam (PF07714) In PDB | Homo sapiens (Human) | Epithelial discoidin domain receptor 1,CD167 antigen-like family member A,Cell adhesion kinase,Discoidin receptor tyrosine kinase,HGK2,Mammary carcinoma kinase 10,MCK-10,Protein-tyrosine kinase 3A,Protein-tyrosine kinase RTK-6,TRK E,Tyrosine kinase DDR,Tyrosine-protein kinase CAK |
2 | A | 2-[8-(2~{H}-indazol-5-ylcarbonyl)-4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-~{N}-methyl-ethanamide | non-polymer | 446.5 | 1 | Chemie (D6W) | |||
3 | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
A: 593 - 913 (UniProt: Q08345)
PDB | External Database | Details |
---|---|---|
- | Gly 711 | deletion |
- | Gln 712 | deletion |
- | Ala 713 | deletion |
- | Ala 714 | deletion |
- | Gln 715 | deletion |
- | Gly 716 | deletion |
His 914 | - | expression tag |
His 915 | - | expression tag |
His 916 | - | expression tag |
His 917 | - | expression tag |
His 918 | - | expression tag |
His 919 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36502.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 446.5 | |
All* | Total formula weight | 36949.4 |