6FER

Crystal Structure of human DDR2 kinase in complex with 2-[4,5-difluoro-2-oxo-1'-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Discoidin domain-containing receptor 2	polymer	309	35743.7	12	UniProt (Q16832) Pfam (PF07714)	Homo sapiens (Human)	Discoidin domain receptor 2,CD167 antigen-like family member B,Discoidin domain-containing receptor tyrosine kinase 2,Neurotrophic tyrosine kinase,receptor-related 3,Receptor protein-tyrosine kinase TKT,Tyrosine-protein kinase TYRO10
2	M, N, O, P, Q... (A, B, C, D, E...)	2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{H}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide	non-polymer		522.4	12	Chemie (D6Q)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 600 - 902 (UniProt: Q16832)

PDB	External Database	Details
His 903	-	expression tag
His 904	-	expression tag
His 905	-	expression tag
His 906	-	expression tag
His 907	-	expression tag
His 908	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	428924.9
Non-Polymers*	Number of molecules	12
	Total formula weight	6269.1
All*	Total formula weight	435194.0

*Water molecules are not included.