6FER
Crystal Structure of human DDR2 kinase in complex with 2-[4,5-difluoro-2-oxo-1'-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Discoidin domain-containing receptor 2 | polymer | 309 | 35743.7 | 12 | UniProt (Q16832) Pfam (PF07714) In PDB | Homo sapiens (Human) | Discoidin domain receptor 2,CD167 antigen-like family member B,Discoidin domain-containing receptor tyrosine kinase 2,Neurotrophic tyrosine kinase,receptor-related 3,Receptor protein-tyrosine kinase TKT,Tyrosine-protein kinase TYRO10 |
2 | A, B, C, D, E... | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{H}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | non-polymer | 522.4 | 12 | Chemie (D6Q) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 600 - 902 (UniProt: Q16832)
PDB | External Database | Details |
---|---|---|
His 903 | - | expression tag |
His 904 | - | expression tag |
His 905 | - | expression tag |
His 906 | - | expression tag |
His 907 | - | expression tag |
His 908 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 428924.9 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 6269.1 | |
All* | Total formula weight | 435194.0 |