Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6FER

Crystal Structure of human DDR2 kinase in complex with 2-[4,5-difluoro-2-oxo-1'-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
A	0016020	cellular_component	membrane
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
B	0016020	cellular_component	membrane
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
C	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
C	0016020	cellular_component	membrane
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
D	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
D	0016020	cellular_component	membrane
E	0004672	molecular_function	protein kinase activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation
E	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
E	0016020	cellular_component	membrane
F	0004672	molecular_function	protein kinase activity
F	0004713	molecular_function	protein tyrosine kinase activity
F	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
F	0005524	molecular_function	ATP binding
F	0006468	biological_process	protein phosphorylation
F	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
F	0016020	cellular_component	membrane
G	0004672	molecular_function	protein kinase activity
G	0004713	molecular_function	protein tyrosine kinase activity
G	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
G	0005524	molecular_function	ATP binding
G	0006468	biological_process	protein phosphorylation
G	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
G	0016020	cellular_component	membrane
H	0004672	molecular_function	protein kinase activity
H	0004713	molecular_function	protein tyrosine kinase activity
H	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
H	0005524	molecular_function	ATP binding
H	0006468	biological_process	protein phosphorylation
H	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
H	0016020	cellular_component	membrane
I	0004672	molecular_function	protein kinase activity
I	0004713	molecular_function	protein tyrosine kinase activity
I	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
I	0005524	molecular_function	ATP binding
I	0006468	biological_process	protein phosphorylation
I	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
I	0016020	cellular_component	membrane
J	0004672	molecular_function	protein kinase activity
J	0004713	molecular_function	protein tyrosine kinase activity
J	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
J	0005524	molecular_function	ATP binding
J	0006468	biological_process	protein phosphorylation
J	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
J	0016020	cellular_component	membrane
K	0004672	molecular_function	protein kinase activity
K	0004713	molecular_function	protein tyrosine kinase activity
K	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
K	0005524	molecular_function	ATP binding
K	0006468	biological_process	protein phosphorylation
K	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
K	0016020	cellular_component	membrane
L	0004672	molecular_function	protein kinase activity
L	0004713	molecular_function	protein tyrosine kinase activity
L	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
L	0005524	molecular_function	ATP binding
L	0006468	biological_process	protein phosphorylation
L	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
L	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue D6Q A 1001

Chain	Residue
A	VAL624
A	MET704
A	PHE753
A	HIS755
A	LEU764
A	ALA774
A	ASP775
A	PHE776
A	ALA653
A	GLU672
A	MET676
A	ILE684
A	ILE685
A	MET699
A	THR701
A	TYR703

site_id	AC2
Number of Residues	17
Details	binding site for residue D6Q B 1001

Chain	Residue
B	VAL624
B	ALA653
B	LYS655
B	GLU672
B	MET676
B	ILE685
B	MET699
B	THR701
B	TYR703
B	MET704
B	LEU748
B	PHE753
B	HIS755
B	ILE773
B	ALA774
B	ASP775
B	PHE776

site_id	AC3
Number of Residues	15
Details	binding site for residue D6Q C 1001

Chain	Residue
C	VAL624
C	ALA653
C	GLU672
C	MET676
C	ILE684
C	MET699
C	THR701
C	TYR703
C	MET704
C	PHE753
C	HIS755
C	LEU764
C	ALA774
C	ASP775
C	PHE776

site_id	AC4
Number of Residues	14
Details	binding site for residue D6Q D 1001

Chain	Residue
D	LEU616
D	VAL624
D	ALA653
D	MET676
D	ILE685
D	MET699
D	THR701
D	TYR703
D	MET704
D	HIS755
D	LEU764
D	ALA774
D	ASP775
D	PHE776

site_id	AC5
Number of Residues	14
Details	binding site for residue D6Q E 1001

Chain	Residue
E	VAL624
E	ALA653
E	LYS655
E	MET676
E	ILE685
E	MET699
E	THR701
E	TYR703
E	MET704
E	PHE753
E	HIS755
E	ALA774
E	ASP775
E	PHE776

site_id	AC6
Number of Residues	17
Details	binding site for residue D6Q F 1001

Chain	Residue
F	LEU616
F	VAL624
F	ALA653
F	LYS655
F	GLU672
F	MET676
F	LEU679
F	ILE685
F	MET699
F	THR701
F	TYR703
F	MET704
F	PHE753
F	HIS755
F	ALA774
F	ASP775
F	PHE776

site_id	AC7
Number of Residues	14
Details	binding site for residue D6Q G 1001

Chain	Residue
G	MET704
G	PHE753
G	HIS755
G	LEU764
G	ILE773
G	ALA774
G	ASP775
G	PHE776
G	VAL624
G	MET676
G	ILE685
G	MET699
G	THR701
G	GLU702

site_id	AC8
Number of Residues	16
Details	binding site for residue D6Q H 1001

Chain	Residue
H	LEU616
H	VAL624
H	ALA653
H	GLU672
H	MET676
H	ILE685
H	MET699
H	THR701
H	TYR703
H	MET704
H	PHE753
H	HIS755
H	LEU764
H	ALA774
H	ASP775
H	PHE776

site_id	AC9
Number of Residues	14
Details	binding site for residue D6Q I 1001

Chain	Residue
I	LEU616
I	VAL624
I	ALA653
I	MET676
I	ILE685
I	MET699
I	THR701
I	TYR703
I	MET704
I	HIS755
I	ILE773
I	ALA774
I	ASP775
I	PHE776

site_id	AD1
Number of Residues	16
Details	binding site for residue D6Q J 1001

Chain	Residue
J	LEU616
J	ALA653
J	MET676
J	ILE684
J	ILE685
J	MET699
J	THR701
J	GLU702
J	TYR703
J	MET704
J	PHE753
J	HIS755
J	ILE773
J	ALA774
J	ASP775
J	PHE776

site_id	AD2
Number of Residues	15
Details	binding site for residue D6Q K 1001

Chain	Residue
K	VAL624
K	ALA653
K	GLU672
K	MET676
K	ILE684
K	ILE685
K	MET699
K	THR701
K	GLU702
K	MET704
K	HIS755
K	ILE773
K	ALA774
K	ASP775
K	PHE776

site_id	AD3
Number of Residues	17
Details	binding site for residue D6Q L 1001

Chain	Residue
L	LEU616
L	LYS655
L	GLU672
L	MET676
L	ILE684
L	ILE685
L	MET699
L	THR701
L	TYR703
L	MET704
L	PHE753
L	HIS755
L	LEU764
L	ILE773
L	ALA774
L	ASP775
L	PHE776

Functional Information from PROSITE/UniProt

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV

Chain	Residue	Details
A	PHE753-VAL765

site_id	PS00239
Number of Residues	9
Details	RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. NLYsgdYYR

Chain	Residue	Details
A	ASN781-ARG789

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP757
J	ASP757
K	ASP757
L	ASP757
B	ASP757
C	ASP757
D	ASP757
E	ASP757
F	ASP757
G	ASP757
H	ASP757
I	ASP757

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU616
J	LEU616
K	LEU616
L	LEU616
B	LEU616
C	LEU616
D	LEU616
E	LEU616
F	LEU616
G	LEU616
H	LEU616
I	LEU616

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	LYS655
J	LYS655
K	LYS655
L	LYS655
B	LYS655
C	LYS655
D	LYS655
E	LYS655
F	LYS655
G	LYS655
H	LYS655
I	LYS655

site_id	SWS_FT_FI4
Number of Residues	36
Details	MOD_RES: Phosphotyrosine; by SRC and autocatalysis => ECO:0000269\|PubMed:16186108

Chain	Residue	Details
A	TYR783
D	TYR783
D	TYR787
D	TYR788
E	TYR783
E	TYR787
E	TYR788
F	TYR783
F	TYR787
F	TYR788
G	TYR783
A	TYR787
G	TYR787
G	TYR788
H	TYR783
H	TYR787
H	TYR788
I	TYR783
I	TYR787
I	TYR788
J	TYR783
J	TYR787
A	TYR788
J	TYR788
K	TYR783
K	TYR787
K	TYR788
L	TYR783
L	TYR787
L	TYR788
B	TYR783
B	TYR787
B	TYR788
C	TYR783
C	TYR787
C	TYR788

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)