6FE7
Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-356
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 364 | 41808.2 | 4 | UniProt (Q08499) Pfam (PF00233) In PDB | Homo sapiens (Human) | DPDE3,PDE43 |
2 | C, B, A, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
3 | C, B, A, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
4 | A, C, D, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 58 | Chemie (EDO) | |||
5 | D, B, C, A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 14 | Chemie (PEG) | |||
6 | D, C, B, A | (4aS,8aR)-2-(1-{2-aminothieno[2,3-d]pyrimidin-4-yl}piperidin-4-yl)-4-(3,4- dimethoxyphenyl)-1,2,4a,5,8,8a-hexahydrophthalazin-1-one | non-polymer | 518.6 | 4 | Chemie (D62) | |||
7 | A, B, C, D | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 5 | Chemie (EPE) | |||
8 | C | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
9 | water | water | 18.0 | 670 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 79 - 438 (UniProt: Q08499)
PDB | External Database | Details |
---|---|---|
Gly 75 | - | expression tag |
Ser 76 | - | expression tag |
His 77 | - | expression tag |
Met 78 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 167233.0 | |
Non-Polymers* | Number of molecules | 91 |
Total formula weight | 9099.0 | |
All* | Total formula weight | 176331.9 |