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6FDC

Crystal structure of the PDE4D catalytic domain in complex with GEBR-32a

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BcAMP-specific 3',5'-cyclic phosphodiesterase 4Dpolymer34339624.92UniProt (Q08499)
Pfam (PF00233)
In PDB
Homo sapiens (Human)DPDE3,PDE43
2A, BZINC IONnon-polymer65.42Chemie (ZN)
3A, BMAGNESIUM IONnon-polymer24.35Chemie (MG)
4A, B1,2-ETHANEDIOLnon-polymer62.12Chemie (EDO)
5A(2~{R})-1-[3-[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]pyrazol-1-yl]-3-morpholin-4-yl-propan-2-olnon-polymer437.51Chemie (DD5)
6B(2~{S})-1-[5-[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]pyrazol-1-yl]-3-morpholin-4-yl-propan-2-olnon-polymer437.51Chemie (D5N)
7waterwater18.0504Chemie (HOH)
Sequence modifications
A, B: 244 - 578 (UniProt: Q08499)
PDBExternal DatabaseDetails
Met 243-initiating methionine
Ala 579-expression tag
His 580-expression tag
His 581-expression tag
His 582-expression tag
His 583-expression tag
His 584-expression tag
His 585-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight79249.9
Non-Polymers*Number of molecules11
Total formula weight1251.4
All*Total formula weight80501.3
*Water molecules are not included.

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PDB entries from 2024-09-18

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