6FDC
Crystal structure of the PDE4D catalytic domain in complex with GEBR-32a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 343 | 39624.9 | 2 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (Human) | DPDE3,PDE43 |
| 2 | C, I (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, F, J, K (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 4 | G, L (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | H (A) | (2~{R})-1-[3-[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]pyrazol-1-yl]-3-morpholin-4-yl-propan-2-ol | non-polymer | 437.5 | 1 | Chemie (DD5) | |||
| 6 | M (B) | (2~{S})-1-[5-[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]pyrazol-1-yl]-3-morpholin-4-yl-propan-2-ol | non-polymer | 437.5 | 1 | Chemie (D5N) | |||
| 7 | N, O (A, B) | water | water | 18.0 | 504 | Chemie (HOH) |
Sequence modifications
A, B: 244 - 578 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Met 243 | - | initiating methionine |
| Ala 579 | - | expression tag |
| His 580 | - | expression tag |
| His 581 | - | expression tag |
| His 582 | - | expression tag |
| His 583 | - | expression tag |
| His 584 | - | expression tag |
| His 585 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79249.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1251.4 | |
| All* | Total formula weight | 80501.3 |
