6FDC

Crystal structure of the PDE4D catalytic domain in complex with GEBR-32a

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	polymer	343	39624.9	2	UniProt (Q08499) Pfam (PF00233) In PDB	Homo sapiens (Human)	DPDE3,PDE43
2	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	A, B	MAGNESIUM ION	non-polymer		24.3	5	Chemie (MG)
4	A, B	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
5	A	(2~{R})-1-[3-[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]pyrazol-1-yl]-3-morpholin-4-yl-propan-2-ol	non-polymer		437.5	1	Chemie (DD5)
6	B	(2~{S})-1-[5-[4-[bis(fluoranyl)methoxy]-3-cyclopentyloxy-phenyl]pyrazol-1-yl]-3-morpholin-4-yl-propan-2-ol	non-polymer		437.5	1	Chemie (D5N)
7		water	water		18.0	504	Chemie (HOH)

Sequence modifications

A, B: 244 - 578 (UniProt: Q08499)

PDB	External Database	Details
Met 243	-	initiating methionine
Ala 579	-	expression tag
His 580	-	expression tag
His 581	-	expression tag
His 582	-	expression tag
His 583	-	expression tag
His 584	-	expression tag
His 585	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	79249.9
Non-Polymers*	Number of molecules	11
	Total formula weight	1251.4
All*	Total formula weight	80501.3

*Water molecules are not included.