6F28
Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2'-Amino-2'-carboxyethyl]-6-methyl-5,7-dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 2.4A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamate receptor ionotropic, kainate 3,Glutamate receptor ionotropic, kainate 3 | polymer | 258 | 29092.5 | 2 | UniProt (P42264) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluK3,Glutamate receptor 7,GluR7,GluK3,Glutamate receptor 7,GluR7 |
| 2 | C, G, H, I, J (A, B) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 3 | D, K (A, B) | (2~{S})-2-azanyl-3-[6-methyl-2,4-bis(oxidanylidene)-5,7-dihydropyrrolo[3,4-d]pyrimidin-1-yl]propanoic acid | non-polymer | 254.2 | 2 | Chemie (CG8) | |||
| 4 | E, F, M (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | L (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | N, O (A, B) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A, B: 4 - 118 (UniProt: P42264)
A, B: 121 - 258 (UniProt: P42264)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Pro 2 | - | cloning artifact |
| Gly 3 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | - | linker |
| Thr 120 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58184.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1038.0 | |
| All* | Total formula weight | 59222.9 |
