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6EZF

PDE2 in complex with molecule 5

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
cGMP-dependent 3',5'-cyclic phosphodiesterasepolymer35341377.31UniProt (O00408)
Pfam (PF00233)
Homo sapiens (Human)Cyclic GMP-stimulated phosphodiesterase,cGSPDE
2B
(A)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
3C
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
4D
(A)
6-[(2,4-dichlorophenyl)methyl]pyridazine-3-thiolnon-polymer271.21Chemie (C6Z)
5E, F
(A)
GLYCEROLnon-polymer92.12Chemie (GOL)
6G
(A)
SULFATE IONnon-polymer96.11Chemie (SO4)
7H
(A)
SODIUM IONnon-polymer23.01Chemie (NA)
8I
(A)
waterwater18.0347Chemie (HOH)
Sequence modifications
A: 578 - 919 (UniProt: O00408)
PDBExternal DatabaseDetails
Met 575-initiating methionine
His 576-expression tag
Ala 577-expression tag
Leu 920-expression tag
Glu 921-expression tag
His 922-expression tag
His 923-expression tag
His 924-expression tag
His 925-expression tag
His 926-expression tag
His 927-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight41377.3
Non-Polymers*Number of molecules7
Total formula weight664.1
All*Total formula weight42041.5
*Water molecules are not included.

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PDB entries from 2025-10-08

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