6EZF

PDE2 in complex with molecule 5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 1001

Chain	Residue
A	ASP697
A	HOH1131
A	HOH1181
A	HOH1216
A	HOH1275
A	HOH1376

---

site_id	AC2
Number of Residues	6
Details	binding site for residue ZN A 1002

Chain	Residue
A	ASP808
A	HOH1181
A	HOH1302
A	HIS660
A	HIS696
A	ASP697

---

site_id	AC3
Number of Residues	9
Details	binding site for residue C6Z A 1003

Chain	Residue
A	ALA717
A	GLN812
A	ILE826
A	TYR827
A	PHE830
A	MET847
A	GLN859
A	PHE862
A	HOH1105

---

site_id	AC4
Number of Residues	9
Details	binding site for residue GOL A 1004

Chain	Residue
A	TYR719
A	LEU774
A	PHE777
A	HIS865
A	PRO869
A	THR903
A	ARG905
A	HOH1121
A	HOH1130

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL A 1005

Chain	Residue
A	GLU864
A	LEU907
A	SER909
A	HOH1111
A	HOH1121
A	HOH1192
A	HOH1303

---

site_id	AC6
Number of Residues	8
Details	binding site for residue SO4 A 1006

Chain	Residue
A	THR606
A	GLY815
A	THR818
A	HOH1101
A	HOH1106
A	HOH1197
A	HOH1231
A	HOH1244

---

site_id	AC7
Number of Residues	3
Details	binding site for residue NA A 1007

Chain	Residue
A	HIS656
A	HOH1302
A	HOH1376

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF

Chain	Residue	Details
A	HIS696-PHE707

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---