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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6EXN

Post-catalytic P complex spliceosome with 3' splice site docked

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(2)		U2 snRNApolymer1175376267.41GenBank (329136699)Saccharomyces cerevisiae S288c
2B
(5)		U5 snRNApolymer17957444.91GenBank (1039024057)Saccharomyces cerevisiae S288c (Baker's yeast)
3C
(6)		U6 snRNApolymer11235883.21GenBank (1039023280)Saccharomyces cerevisiae S288c (Baker's yeast)
4D
(A)		Pre-mRNA-splicing factor Prp8polymer2413279867.51UniProt (P33334)
Pfam (PF08082)
Pfam (PF08083)
Pfam (PF10598)
Pfam (PF10597)
Pfam (PF10596)
Pfam (PF12134)
Pfam (PF08084)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
5E
(C)		Pre-mRNA-splicing factor SNU114polymer1008114174.01UniProt (P36048)
Pfam (PF03764)
Pfam (PF00679)
Pfam (PF16004)
Pfam (PF00009)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)114 kDa U5 small nuclear ribonucleoprotein component,Growth inhibitory protein 10
6F
(D)		Pre-mRNA-splicing factor CWC16polymer27832371.11UniProt (P28320)
Pfam (PF04502)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
7G
(E)		Ligated exons: UBC4 mRNApolymer3912523.51Saccharomyces cerevisiae S288c
8H
(H)		Pre-mRNA-splicing factor CWC22polymer57767386.11UniProt (P53333)
Pfam (PF02847)		Saccharomyces cerevisiae (Baker's yeast)Complexed with CEF1 protein 22
9I
(I)		Intron lariat: UBC4 RNApolymer9530200.71GenBank (329136699)Saccharomyces cerevisiae S288c
10J
(J)		Pre-mRNA-splicing factor PRP46polymer45150801.31UniProt (Q12417)
Pfam (PF00400)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complexed with CEF1 protein 1,PRP nineteen-associated complex protein 50,PRP19-associated complex protein 50,Pre-mRNA-processing protein 46
11K
(K)		Pre-mRNA-processing protein 45polymer37942548.71UniProt (P28004)
Pfam (PF02731)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
12L
(L)		Pre-mRNA-splicing factor BUD31polymer15718484.51UniProt (P25337)
Pfam (PF01125)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Bud site selection protein 31,Complexed with CEF1 protein 14
13M
(M)		Pre-mRNA-splicing factor CWC2polymer33938486.61UniProt (Q12046)
Pfam (PF16131)
Pfam (PF00076)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complexed with CEF1 protein 2,PRP19-associated complex protein 40,Synthetic lethal with CLF1 protein 3
14N
(N)		Pre-mRNA-splicing factor SLT11polymer36440988.61UniProt (P38241)
Pfam (PF21369)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Extracellular mutant protein 2,Synthetic lethality with U2 protein 11
15O
(O)		Pre-mRNA-splicing factor CEF1polymer59067829.81UniProt (Q03654)
Pfam (PF00249)
Pfam (PF11831)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)PRP nineteen-associated complex protein 85,PRP19-associated complex protein 85
16P
(P)		Pre-mRNA-splicing factor CWC15polymer17519970.21UniProt (Q03772)
Pfam (PF04889)		Saccharomyces cerevisiae (Baker's yeast)Complexed with CEF1 protein 15
17Q
(R)		Pre-mRNA-splicing factor CWC21polymer13515793.61UniProt (Q03375)
Pfam (PF08312)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complexed with CEF1 protein 21
18R
(S)		Pre-mRNA-splicing factor CLF1polymer68782560.91UniProt (Q12309)
Pfam (PF05843)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Crooked neck-like factor 1,PRP19-associated complex protein 77,Synthetic lethal with CDC40 protein 3
19S
(T)		Pre-mRNA-splicing factor SYF1polymer859100356.11UniProt (Q04048)
Pfam (PF05843)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)PRP19-associated complex protein 90,Synthetic lethal with CDC40 protein 1
20T
(V)		Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22polymer1145130187.41UniProt (P24384)
Pfam (PF00575)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF04408)
Pfam (PF21010)
Pfam (PF07717)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
21U
(W)		U2 small nuclear ribonucleoprotein A'polymer23827232.31UniProt (Q08963)
Pfam (PF14580)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)U2 snRNP A',Looks exceptionally like U2A protein 1
22V
(X)		Unassigned structurepolymer958103.01Saccharomyces cerevisiae S288c (Baker's yeast)
23W
(Y)		U2 small nuclear ribonucleoprotein B''polymer11112850.91UniProt (P40567)
Pfam (PF13893)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)U2 snRNP B''
24X
(a)		Pre-mRNA-splicing factor Prp18polymer25128414.41UniProt (P33411)
Pfam (PF02840)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
25GA, Y
(b, k)		Small nuclear ribonucleoprotein-associated protein Bpolymer19622427.02UniProt (P40018)
Pfam (PF01423)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)snRNP-B,Sm protein B,SmB
26Z
(c)		Pre-mRNA-splicing factor SLU7polymer38244722.91UniProt (Q02775)
Pfam (PF11708)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Synthetic lethal with U2 snRNA protein 17,Synthetic lethal with U5 snRNA protein 7
27AA, JA
(d, n)		Small nuclear ribonucleoprotein Sm D3polymer10111240.12UniProt (P43321)
Pfam (PF01423)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Sm-D3,snRNP core protein D3
28BA, LA
(e, p)		Small nuclear ribonucleoprotein Epolymer9410385.12UniProt (Q12330)
Pfam (PF01423)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)snRNP-E,Sm protein E,SmE
29CA, MA
(f, q)		Small nuclear ribonucleoprotein Fpolymer869669.92UniProt (P54999)
Pfam (PF01423)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)snRNP-F,Sm protein F,SmF
30DA, NA
(g, r)		Small nuclear ribonucleoprotein Gpolymer778490.82UniProt (P40204)
Pfam (PF01423)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)snRNP-G,Sm protein G,SmG
31EA, HA
(h, l)		Small nuclear ribonucleoprotein Sm D1polymer14616296.82UniProt (Q02260)
Pfam (PF01423)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Sm-D1,snRNP core protein D1
32FA, IA
(j, m)		Small nuclear ribonucleoprotein Sm D2polymer11012876.12UniProt (Q06217)
Pfam (PF01423)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Sm-D2,snRNP core protein D2
33KA
(o)		Pre-mRNA-processing factor Prp17polymer45552128.81UniProt (P40968)
Pfam (PF00400)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Cell division control protein 40
34OA
(s)		Pre-mRNA-splicing factor SNT309polymer17520741.51UniProt (Q06091)Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)PRP19-associated complex protein 25,Synergistic to PRP19 mutation protein 309
35PA, QA, RA, SA
(t, u, v, w)		Pre-mRNA-processing factor Prp19polymer50356629.84UniProt (P32523)
Pfam (PF08606)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)RING-type E3 ubiquitin transferase PRP19
36TA
(y)		Pre-mRNA-splicing factor SYF2polymer21524850.71UniProt (P53277)
Pfam (PF08231)		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)PRP19 complex protein 31,Synthetic lethal with CDC40 protein 2
37UA
(6)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
38VA
(A)		INOSITOL HEXAKISPHOSPHATEnon-polymer660.01Chemie (IHP)
39WA
(C)		GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
40AB, BB, CB, DB, XA...
(M, N, c, L)		ZINC IONnon-polymer65.47Chemie (ZN)
Sequence modifications
J: 1 - 451 (UniProt: Q12417)
PDBExternal DatabaseDetails
Thr 80Ala 80conflict
O: 1 - 590 (UniProt: Q03654)
PDBExternal DatabaseDetails
Val 125Ala 125conflict
Pro 285Ser 285conflict
Glu 341Asp 341conflict
Pro 342Ser 342conflict
Ser 417Pro 417conflict
Pro 425Arg 425conflict
P: 1 - 175 (UniProt: Q03772)
PDBExternal DatabaseDetails
Lys 49Arg 49conflict
Asn 58Ser 58conflict
Val 66Ala 66conflict
Val 68Met 68conflict
S: 1 - 687 (UniProt: Q12309)
PDBExternal DatabaseDetails
Lys 561Glu 561conflict
Met 615Leu 615conflict
Asp 649Asn 649conflict
Val 659Ile 659conflict
T: 1 - 859 (UniProt: Q04048)
PDBExternal DatabaseDetails
Ile 695Thr 695conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains46
Total formula weight2242461.1
Non-Polymers*Number of molecules10
Total formula weight1665.4
All*Total formula weight2244126.5
*Water molecules are not included.

246905

PDB entries from 2025-12-31

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