6EWX

Structure of Pragmin pseudo-kinase reveals a dimerization mechanism to regulate protein tyrosine phosphorylation and nuclear transcription

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	PEAK1-related kinase-activating pseudokinase 1	polymer	484	53864.7	2	UniProt (D3ZMK9) Pfam (PF00069)	Rattus norvegicus (Rat)	Similar to DNA segment,Chr 8,ERATO Doi 82,expressed (Predicted),isoform CRA_a
2	C, D (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	E, F (A, B)	water	water		18.0	49	Chemie (HOH)

Sequence modifications

A, B: 906 - 1368 (UniProt: D3ZMK9)

PDB	External Database	Details
Met 885	-	initiating methionine
Gly 886	-	expression tag
Ser 887	-	expression tag
Ser 888	-	expression tag
His 889	-	expression tag
His 890	-	expression tag
His 891	-	expression tag
His 892	-	expression tag
His 893	-	expression tag
His 894	-	expression tag
Ser 895	-	expression tag
Ser 896	-	expression tag
Gly 897	-	expression tag
Leu 898	-	expression tag
Val 899	-	expression tag
Pro 900	-	expression tag
Arg 901	-	expression tag
Gly 902	-	expression tag
Ser 903	-	expression tag
His 904	-	expression tag
Met 905	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	107729.4
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	107921.5

*Water molecules are not included.