6ERP

Structure of the human mitochondrial transcription initiation complex at the LSP promoter

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (C, G)	Transcription factor A, mitochondrial	polymer	205	24516.2	2	UniProt (Q00059) Pfam (PF00505) Pfam (PF09011)	Homo sapiens (Human)	mtTFA,Mitochondrial transcription factor 1,MtTF1,Transcription factor 6,TCF-6,Transcription factor 6-like 2
2	B, E (D, H)	Non-Template DNA	polymer	50	15488.9	2		Homo sapiens
3	C, F (E, I)	Template DNA	polymer	50	15232.8	2		Homo sapiens
4	G, H (A, B)	DNA-directed RNA polymerase, mitochondrial	polymer	1128	127904.1	2	UniProt (O00411) Pfam (PF14700) Pfam (PF00940)	Homo sapiens (Human)	MtRPOL
5	I, J (F, J)	Dimethyladenosine transferase 2, mitochondrial	polymer	377	43383.3	2	UniProt (Q9H5Q4) Pfam (PF00398)	Homo sapiens (Human)	Hepatitis C virus NS5A-transactivated protein 5,HCV NS5A-transactivated protein 5,Mitochondrial 12S rRNA dimethylase 2,Mitochondrial transcription factor B2,mtTFB2,S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase 2

Sequence modifications

C, G: 43 - 245 (UniProt: Q00059)

PDB	External Database	Details
Asn 41	-	expression tag
Ala 42	-	expression tag
Ser 49	Cys 49	conflict

A, B: 105 - 1230 (UniProt: O00411)

PDB	External Database	Details
Asn 103	-	expression tag
Ala 104	-	expression tag
Ala 555	Glu 555	engineered mutation

F, J: 21 - 396 (UniProt: Q9H5Q4)

PDB	External Database	Details
Asn 20	-	expression tag
Ala 21	Gly 21	conflict

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	453050.4
All*	Total formula weight	453050.4

*Water molecules are not included.