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6ERP

Structure of the human mitochondrial transcription initiation complex at the LSP promoter

Functional Information from GO Data
ChainGOidnamespacecontents
A0000175molecular_function3'-5'-RNA exonuclease activity
A0000428cellular_componentDNA-directed RNA polymerase complex
A0001018molecular_functionmitochondrial promoter sequence-specific DNA binding
A0003677molecular_functionDNA binding
A0003723molecular_functionRNA binding
A0003896molecular_functionDNA primase activity
A0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006269biological_processDNA replication, synthesis of primer
A0006351biological_processDNA-templated transcription
A0006390biological_processmitochondrial transcription
A0006391biological_processtranscription initiation at mitochondrial promoter
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0032991cellular_componentprotein-containing complex
A0034062molecular_function5'-3' RNA polymerase activity
A0034245cellular_componentmitochondrial DNA-directed RNA polymerase complex
A0042645cellular_componentmitochondrial nucleoid
A0043565molecular_functionsequence-specific DNA binding
B0000175molecular_function3'-5'-RNA exonuclease activity
B0000428cellular_componentDNA-directed RNA polymerase complex
B0001018molecular_functionmitochondrial promoter sequence-specific DNA binding
B0003677molecular_functionDNA binding
B0003723molecular_functionRNA binding
B0003896molecular_functionDNA primase activity
B0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006269biological_processDNA replication, synthesis of primer
B0006351biological_processDNA-templated transcription
B0006390biological_processmitochondrial transcription
B0006391biological_processtranscription initiation at mitochondrial promoter
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0032991cellular_componentprotein-containing complex
B0034062molecular_function5'-3' RNA polymerase activity
B0034245cellular_componentmitochondrial DNA-directed RNA polymerase complex
B0042645cellular_componentmitochondrial nucleoid
B0043565molecular_functionsequence-specific DNA binding
F0000154biological_processrRNA modification
F0000179molecular_functionrRNA (adenine-N6,N6-)-dimethyltransferase activity
F0003723molecular_functionRNA binding
F0005739cellular_componentmitochondrion
F0005759cellular_componentmitochondrial matrix
F0006364biological_processrRNA processing
F0006390biological_processmitochondrial transcription
F0006391biological_processtranscription initiation at mitochondrial promoter
F0008168molecular_functionmethyltransferase activity
F0016740molecular_functiontransferase activity
F0031167biological_processrRNA methylation
F0032259biological_processmethylation
F0034246molecular_functionmitochondrial transcription factor activity
F0042645cellular_componentmitochondrial nucleoid
J0000154biological_processrRNA modification
J0000179molecular_functionrRNA (adenine-N6,N6-)-dimethyltransferase activity
J0003723molecular_functionRNA binding
J0005739cellular_componentmitochondrion
J0005759cellular_componentmitochondrial matrix
J0006364biological_processrRNA processing
J0006390biological_processmitochondrial transcription
J0006391biological_processtranscription initiation at mitochondrial promoter
J0008168molecular_functionmethyltransferase activity
J0016740molecular_functiontransferase activity
J0031167biological_processrRNA methylation
J0032259biological_processmethylation
J0034246molecular_functionmitochondrial transcription factor activity
J0042645cellular_componentmitochondrial nucleoid
Functional Information from PROSITE/UniProt
site_idPS00489
Number of Residues15
DetailsRNA_POL_PHAGE_2 Bacteriophage-type RNA polymerase family active site signature 2. ItRkvvKqtVMTvvY
ChainResidueDetails
AILE985-TYR999

site_idPS00900
Number of Residues12
DetailsRNA_POL_PHAGE_1 Bacteriophage-type RNA polymerase family active site signature 1. PVhqDGSCNGLQ
ChainResidueDetails
APRO918-GLN929

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
AASP922
ALYS991
AASP1151
BASP922
BLYS991
BASP1151

site_idSWS_FT_FI2
Number of Residues128
DetailsDNA_BIND: HMG box 2 => ECO:0000255|PROSITE-ProRule:PRU00267
ChainResidueDetails
CPRO155-GLU219
GPRO155-GLU219

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Intercalates between bases and promotes DNA bending
ChainResidueDetails
CLEU58
CLEU182
GLEU58
GLEU182

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:23201127
ChainResidueDetails
CSER55
CSER56
CSER61
CSER160
GSER55
GSER56
GSER61
GSER160

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CTHR122
GTHR122

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER193
GSER193

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER195
GSER195

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PDB entries from 2024-04-24

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