6ERP

Structure of the human mitochondrial transcription initiation complex at the LSP promoter

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000175	molecular_function	3'-5'-RNA exonuclease activity
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0001018	molecular_function	mitochondrial promoter sequence-specific DNA binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006264	biological_process	mitochondrial DNA replication
A	0006351	biological_process	DNA-templated transcription
A	0006390	biological_process	mitochondrial transcription
A	0006391	biological_process	transcription initiation at mitochondrial promoter
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0032991	cellular_component	protein-containing complex
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0034245	cellular_component	mitochondrial DNA-directed RNA polymerase complex
A	0042645	cellular_component	mitochondrial nucleoid
A	0043565	molecular_function	sequence-specific DNA binding
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0001018	molecular_function	mitochondrial promoter sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006264	biological_process	mitochondrial DNA replication
B	0006351	biological_process	DNA-templated transcription
B	0006390	biological_process	mitochondrial transcription
B	0006391	biological_process	transcription initiation at mitochondrial promoter
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0032991	cellular_component	protein-containing complex
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0034245	cellular_component	mitochondrial DNA-directed RNA polymerase complex
B	0042645	cellular_component	mitochondrial nucleoid
B	0043565	molecular_function	sequence-specific DNA binding
F	0000154	biological_process	rRNA modification
F	0000179	molecular_function	rRNA (adenine-N6,N6-)-dimethyltransferase activity
F	0003723	molecular_function	RNA binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006364	biological_process	rRNA processing
F	0006390	biological_process	mitochondrial transcription
F	0006391	biological_process	transcription initiation at mitochondrial promoter
F	0008168	molecular_function	methyltransferase activity
F	0008988	molecular_function	rRNA (adenine-N6-)-methyltransferase activity
F	0016740	molecular_function	transferase activity
F	0031167	biological_process	rRNA methylation
F	0032259	biological_process	methylation
F	0034246	molecular_function	mitochondrial transcription factor activity
F	0042645	cellular_component	mitochondrial nucleoid
J	0000154	biological_process	rRNA modification
J	0000179	molecular_function	rRNA (adenine-N6,N6-)-dimethyltransferase activity
J	0003723	molecular_function	RNA binding
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0006364	biological_process	rRNA processing
J	0006390	biological_process	mitochondrial transcription
J	0006391	biological_process	transcription initiation at mitochondrial promoter
J	0008168	molecular_function	methyltransferase activity
J	0008988	molecular_function	rRNA (adenine-N6-)-methyltransferase activity
J	0016740	molecular_function	transferase activity
J	0031167	biological_process	rRNA methylation
J	0032259	biological_process	methylation
J	0034246	molecular_function	mitochondrial transcription factor activity
J	0042645	cellular_component	mitochondrial nucleoid

Functional Information from PROSITE/UniProt

site_id	PS00489
Number of Residues	15
Details	RNA_POL_PHAGE_2 Bacteriophage-type RNA polymerase family active site signature 2. ItRkvvKqtVMTvvY

Chain	Residue	Details
A	ILE985-TYR999

---

site_id	PS00900
Number of Residues	12
Details	RNA_POL_PHAGE_1 Bacteriophage-type RNA polymerase family active site signature 1. PVhqDGSCNGLQ

Chain	Residue	Details
A	PRO918-GLN929

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	136
Details	DNA binding: {"description":"HMG box 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00267","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	128
Details	DNA binding: {"description":"HMG box 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00267","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Intercalates between bases and promotes DNA bending"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"23201127","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"29149603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ERP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ERQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01026","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---